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Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002–2003 and MERS in 2012. So far, there are alm...

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Detalles Bibliográficos
Autores principales: Chen, Xiangyan, Han, Wenwei, Wang, Guixiang, Zhao, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358770/
https://www.ncbi.nlm.nih.gov/pubmed/32679328
http://dx.doi.org/10.1016/j.ijbiomac.2020.07.106
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author Chen, Xiangyan
Han, Wenwei
Wang, Guixiang
Zhao, Xia
author_facet Chen, Xiangyan
Han, Wenwei
Wang, Guixiang
Zhao, Xia
author_sort Chen, Xiangyan
collection PubMed
description Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002–2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines.
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spelling pubmed-73587702020-07-14 Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines Chen, Xiangyan Han, Wenwei Wang, Guixiang Zhao, Xia Int J Biol Macromol Review Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002–2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines. Elsevier B.V. 2020-12-01 2020-07-14 /pmc/articles/PMC7358770/ /pubmed/32679328 http://dx.doi.org/10.1016/j.ijbiomac.2020.07.106 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Chen, Xiangyan
Han, Wenwei
Wang, Guixiang
Zhao, Xia
Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
title Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
title_full Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
title_fullStr Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
title_full_unstemmed Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
title_short Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
title_sort application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358770/
https://www.ncbi.nlm.nih.gov/pubmed/32679328
http://dx.doi.org/10.1016/j.ijbiomac.2020.07.106
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