The diffuse-type gastric cancer epidemiology enigma

BACKGROUND: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. R...

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Detalles Bibliográficos
Autores principales: Assumpção, Paulo Pimentel, Barra, Williams Fernandes, Ishak, Geraldo, Coelho, Luiz Gonzaga Vaz, Coimbra, Felipe José Fernandez, Freitas, Helano Carioca, Dias-Neto, Emmanuel, Camargo, M. Constanza, Szklo, Moyses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358925/
https://www.ncbi.nlm.nih.gov/pubmed/32660428
http://dx.doi.org/10.1186/s12876-020-01354-4
Descripción
Sumario:BACKGROUND: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. RESULTS: Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood. CONCLUSIONS: Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach’s microenvironment.

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