The diffuse-type gastric cancer epidemiology enigma

BACKGROUND: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. R...

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Autores principales: Assumpção, Paulo Pimentel, Barra, Williams Fernandes, Ishak, Geraldo, Coelho, Luiz Gonzaga Vaz, Coimbra, Felipe José Fernandez, Freitas, Helano Carioca, Dias-Neto, Emmanuel, Camargo, M. Constanza, Szklo, Moyses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358925/
https://www.ncbi.nlm.nih.gov/pubmed/32660428
http://dx.doi.org/10.1186/s12876-020-01354-4
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author Assumpção, Paulo Pimentel
Barra, Williams Fernandes
Ishak, Geraldo
Coelho, Luiz Gonzaga Vaz
Coimbra, Felipe José Fernandez
Freitas, Helano Carioca
Dias-Neto, Emmanuel
Camargo, M. Constanza
Szklo, Moyses
author_facet Assumpção, Paulo Pimentel
Barra, Williams Fernandes
Ishak, Geraldo
Coelho, Luiz Gonzaga Vaz
Coimbra, Felipe José Fernandez
Freitas, Helano Carioca
Dias-Neto, Emmanuel
Camargo, M. Constanza
Szklo, Moyses
author_sort Assumpção, Paulo Pimentel
collection PubMed
description BACKGROUND: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. RESULTS: Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood. CONCLUSIONS: Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach’s microenvironment.
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spelling pubmed-73589252020-07-17 The diffuse-type gastric cancer epidemiology enigma Assumpção, Paulo Pimentel Barra, Williams Fernandes Ishak, Geraldo Coelho, Luiz Gonzaga Vaz Coimbra, Felipe José Fernandez Freitas, Helano Carioca Dias-Neto, Emmanuel Camargo, M. Constanza Szklo, Moyses BMC Gastroenterol Debate BACKGROUND: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. RESULTS: Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood. CONCLUSIONS: Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach’s microenvironment. BioMed Central 2020-07-13 /pmc/articles/PMC7358925/ /pubmed/32660428 http://dx.doi.org/10.1186/s12876-020-01354-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Debate
Assumpção, Paulo Pimentel
Barra, Williams Fernandes
Ishak, Geraldo
Coelho, Luiz Gonzaga Vaz
Coimbra, Felipe José Fernandez
Freitas, Helano Carioca
Dias-Neto, Emmanuel
Camargo, M. Constanza
Szklo, Moyses
The diffuse-type gastric cancer epidemiology enigma
title The diffuse-type gastric cancer epidemiology enigma
title_full The diffuse-type gastric cancer epidemiology enigma
title_fullStr The diffuse-type gastric cancer epidemiology enigma
title_full_unstemmed The diffuse-type gastric cancer epidemiology enigma
title_short The diffuse-type gastric cancer epidemiology enigma
title_sort diffuse-type gastric cancer epidemiology enigma
topic Debate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358925/
https://www.ncbi.nlm.nih.gov/pubmed/32660428
http://dx.doi.org/10.1186/s12876-020-01354-4
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