cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4

Direct regulation of the pacemaker “funny” current (I(f)) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive I(f) in sinoatrial node (SAN) myocytes....

Descripción completa

Detalles Bibliográficos
Autores principales: Porro, Alessandro, Thiel, Gerhard, Moroni, Anna, Saponaro, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358946/
https://www.ncbi.nlm.nih.gov/pubmed/32733276
http://dx.doi.org/10.3389/fphys.2020.00771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358946/
https://www.ncbi.nlm.nih.gov/pubmed/32733276
http://dx.doi.org/10.3389/fphys.2020.00771

Ejemplares similares