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Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis
BACKGROUND: Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP). METHODS: We retrospectively collected...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359019/ https://www.ncbi.nlm.nih.gov/pubmed/32660430 http://dx.doi.org/10.1186/s12876-020-01243-w |
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author | Xie, Xiaochun Dong, Jie Lu, Guotao Gao, Kun Li, Xiaoyao Mao, Wenjian Chen, Faxi Tong, Zhihui Li, Baiqiang Li, Weiqin |
author_facet | Xie, Xiaochun Dong, Jie Lu, Guotao Gao, Kun Li, Xiaoyao Mao, Wenjian Chen, Faxi Tong, Zhihui Li, Baiqiang Li, Weiqin |
author_sort | Xie, Xiaochun |
collection | PubMed |
description | BACKGROUND: Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP). METHODS: We retrospectively collected data on patients diagnosed with AP in a tertiary center from 01 January 2014 to 31 December 2016. The highest TBA value during the first 1,2,3,5,7 days after admission was determined as D1, D2, D3, D5, D7 TBA(max). Patients were divided into the high TBA (HTBA) group and the normal TBA (NTBA) group according to whether the TBA(max) was ≥10 μmol/L. The prognosis and complications, including death, organ failure (OF) and pancreatic necrosis, were compared between the two groups. Logistic regression analysis and receiving operating characteristic (ROC) curve were used to evaluate the relationship between circulating TBA and organ failure in AP patients. RESULTS: Through stratified analysis of each time period, we found that the incidence of OF in the HTBA group was significantly higher than that in the NTBA group, and the AP severity classification in the HTBA group was more serious than that in the NTBA group. In addition, according to the D7 TBA(max) values, the pancreatic necrosis rate, percutaneous catheter drainage (PCD) rate and mortality in the HTBA group were higher than those in the NTBA group. Multivariate regression analysis showed that HTBA (odds ratio (OR), 4.894; P = 0.002) was an independent risk factor for AP complicated with OF, which was verified in the grouping based on D7 TBA(max). ROC analysis revealed that a circulating D7 TBA(max) cutoff point of 6.450 umol/L had optimal predictive value for the development of OF in AP patients with an area under the curve of the ROC curve (AUCROC) of 0.777. CONCLUSIONS: The increase of circulating TBA in early stage of AP is independently related to organ failure, which indicates the adverse prognosis of AP patients. |
format | Online Article Text |
id | pubmed-7359019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73590192020-07-17 Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis Xie, Xiaochun Dong, Jie Lu, Guotao Gao, Kun Li, Xiaoyao Mao, Wenjian Chen, Faxi Tong, Zhihui Li, Baiqiang Li, Weiqin BMC Gastroenterol Research Article BACKGROUND: Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP). METHODS: We retrospectively collected data on patients diagnosed with AP in a tertiary center from 01 January 2014 to 31 December 2016. The highest TBA value during the first 1,2,3,5,7 days after admission was determined as D1, D2, D3, D5, D7 TBA(max). Patients were divided into the high TBA (HTBA) group and the normal TBA (NTBA) group according to whether the TBA(max) was ≥10 μmol/L. The prognosis and complications, including death, organ failure (OF) and pancreatic necrosis, were compared between the two groups. Logistic regression analysis and receiving operating characteristic (ROC) curve were used to evaluate the relationship between circulating TBA and organ failure in AP patients. RESULTS: Through stratified analysis of each time period, we found that the incidence of OF in the HTBA group was significantly higher than that in the NTBA group, and the AP severity classification in the HTBA group was more serious than that in the NTBA group. In addition, according to the D7 TBA(max) values, the pancreatic necrosis rate, percutaneous catheter drainage (PCD) rate and mortality in the HTBA group were higher than those in the NTBA group. Multivariate regression analysis showed that HTBA (odds ratio (OR), 4.894; P = 0.002) was an independent risk factor for AP complicated with OF, which was verified in the grouping based on D7 TBA(max). ROC analysis revealed that a circulating D7 TBA(max) cutoff point of 6.450 umol/L had optimal predictive value for the development of OF in AP patients with an area under the curve of the ROC curve (AUCROC) of 0.777. CONCLUSIONS: The increase of circulating TBA in early stage of AP is independently related to organ failure, which indicates the adverse prognosis of AP patients. BioMed Central 2020-07-13 /pmc/articles/PMC7359019/ /pubmed/32660430 http://dx.doi.org/10.1186/s12876-020-01243-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Xie, Xiaochun Dong, Jie Lu, Guotao Gao, Kun Li, Xiaoyao Mao, Wenjian Chen, Faxi Tong, Zhihui Li, Baiqiang Li, Weiqin Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
title | Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
title_full | Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
title_fullStr | Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
title_full_unstemmed | Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
title_short | Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
title_sort | increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359019/ https://www.ncbi.nlm.nih.gov/pubmed/32660430 http://dx.doi.org/10.1186/s12876-020-01243-w |
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