Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

[Image: see text] Phenotypic whole-cell screening against Mycobacterium tuberculosis (Mtb) in glycerol–alanine–salts supplemented with Tween 80 and iron (GASTE-Fe) media led to the identification of a 2-aminoquinazolinone hit compound, sulfone 1 which was optimized for solubility by replacing the su...

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Detalles Bibliográficos
Autores principales: Akester, Jessica N., Njaria, Paul, Nchinda, Aloysius, Le Manach, Claire, Myrick, Alissa, Singh, Vinayak, Lawrence, Nina, Njoroge, Mathew, Taylor, Dale, Moosa, Atica, Smith, Anthony J., Brooks, Elizabeth J., Lenaerts, Anne J., Robertson, Gregory T., Ioerger, Thomas R., Mueller, Rudolf, Chibale, Kelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359024/
https://www.ncbi.nlm.nih.gov/pubmed/32470286
http://dx.doi.org/10.1021/acsinfecdis.0c00252

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