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Peptides based on the reactive center loop of Manduca sexta serpin-3 block its protease inhibitory function
One innate immune response in insects is the proteolytic activation of hemolymph prophenoloxidase (proPO), regulated by protease inhibitors called serpins. In the inhibition reaction of serpins, a protease cleaves a peptide bond in a solvent-exposed reactive center loop (RCL) of the serpin, and the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359039/ https://www.ncbi.nlm.nih.gov/pubmed/32661389 http://dx.doi.org/10.1038/s41598-020-68316-4 |