Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors

Purpose: Given that heterogeneous expression and variants of antigens on solid tumors are responsible for relapse after chimeric antigen receptor (CAR)-T cell therapy, we hypothesized that combinatorial targeting two tumor-associated antigens would lessen this problem and enhance the antitumor activ...

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Detalles Bibliográficos
Autores principales: Yang, Meijia, Tang, Xin, Zhang, Zongliang, Gu, Lei, Wei, Heng, Zhao, Shasha, Zhong, Kunhong, Mu, Min, Huang, Cheng, Jiang, Caiying, Xu, Jianguo, Guo, Gang, Zhou, Liangxue, Tong, Aiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359081/
https://www.ncbi.nlm.nih.gov/pubmed/32685008
http://dx.doi.org/10.7150/thno.43991

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