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Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients
PURPOSE: Progressive loss (sarcopenia) and fatty infiltration of muscle mass (myosteatosis) are well-established risk factors for an adverse clinical outcome in obese patients. Data concerning non-obese sarcopenic patients in oncologic surgery are scarce and heterogeneous. The aim of this study was...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359173/ https://www.ncbi.nlm.nih.gov/pubmed/32504206 http://dx.doi.org/10.1007/s00423-020-01901-3 |
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author | Schaffler-Schaden, Dagmar Mittermair, Christof Birsak, Theresa Weiss, Michael Hell, Tobias Schaffler, Gottfried Weiss, Helmut |
author_facet | Schaffler-Schaden, Dagmar Mittermair, Christof Birsak, Theresa Weiss, Michael Hell, Tobias Schaffler, Gottfried Weiss, Helmut |
author_sort | Schaffler-Schaden, Dagmar |
collection | PubMed |
description | PURPOSE: Progressive loss (sarcopenia) and fatty infiltration of muscle mass (myosteatosis) are well-established risk factors for an adverse clinical outcome in obese patients. Data concerning non-obese sarcopenic patients in oncologic surgery are scarce and heterogeneous. The aim of this study was to determine the impact of sarcopenia and myosteatosis in non-obese patients with cancer of the right colon on clinical outcome. METHODS: This study comprised 85 patients with a BMI < 30 kg/m(2), who underwent surgery for right colon cancer in a single center. Skeletal muscle area (SMA), visceral fat area (VFA), and myosteatosis were retrospectively assessed using preoperative abdominal CT images. Univariate und multivariate analysis was performed to evaluate the association between body composition, complications, and oncologic follow-up. RESULTS: Traditional risk factors such as visceral fat (p = 0.8653), BMI (p = 0.8033), myosteatosis (p = 0.7705), and sarcopenia (p = 0.3359) failed to show any impact on postoperative complications or early recurrence. In our cohort, the skeletal muscle index (SMI) was the only significant predictor for early cancer recurrence (p = 0.0467). CONCLUSION: SMI is a significant prognostic factor for early cancer recurrence in non-obese colon cancer patients. Our study shows that conventional thresholds for sarcopenia and BMI do not seem to be reliable across various cohorts. Target prehabilitation programs could be useful to improve outcome after colorectal surgery. TRIAL REGISTRATION: DRKS00014655, www.apps.who.int/trialsearch |
format | Online Article Text |
id | pubmed-7359173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73591732020-07-16 Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients Schaffler-Schaden, Dagmar Mittermair, Christof Birsak, Theresa Weiss, Michael Hell, Tobias Schaffler, Gottfried Weiss, Helmut Langenbecks Arch Surg Original Article PURPOSE: Progressive loss (sarcopenia) and fatty infiltration of muscle mass (myosteatosis) are well-established risk factors for an adverse clinical outcome in obese patients. Data concerning non-obese sarcopenic patients in oncologic surgery are scarce and heterogeneous. The aim of this study was to determine the impact of sarcopenia and myosteatosis in non-obese patients with cancer of the right colon on clinical outcome. METHODS: This study comprised 85 patients with a BMI < 30 kg/m(2), who underwent surgery for right colon cancer in a single center. Skeletal muscle area (SMA), visceral fat area (VFA), and myosteatosis were retrospectively assessed using preoperative abdominal CT images. Univariate und multivariate analysis was performed to evaluate the association between body composition, complications, and oncologic follow-up. RESULTS: Traditional risk factors such as visceral fat (p = 0.8653), BMI (p = 0.8033), myosteatosis (p = 0.7705), and sarcopenia (p = 0.3359) failed to show any impact on postoperative complications or early recurrence. In our cohort, the skeletal muscle index (SMI) was the only significant predictor for early cancer recurrence (p = 0.0467). CONCLUSION: SMI is a significant prognostic factor for early cancer recurrence in non-obese colon cancer patients. Our study shows that conventional thresholds for sarcopenia and BMI do not seem to be reliable across various cohorts. Target prehabilitation programs could be useful to improve outcome after colorectal surgery. TRIAL REGISTRATION: DRKS00014655, www.apps.who.int/trialsearch Springer Berlin Heidelberg 2020-06-05 2020 /pmc/articles/PMC7359173/ /pubmed/32504206 http://dx.doi.org/10.1007/s00423-020-01901-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Schaffler-Schaden, Dagmar Mittermair, Christof Birsak, Theresa Weiss, Michael Hell, Tobias Schaffler, Gottfried Weiss, Helmut Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
title | Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
title_full | Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
title_fullStr | Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
title_full_unstemmed | Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
title_short | Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
title_sort | skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359173/ https://www.ncbi.nlm.nih.gov/pubmed/32504206 http://dx.doi.org/10.1007/s00423-020-01901-3 |
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