Cargando…

Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs

BACKGROUND: Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics of senescent cells; however, whether mTORC1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hailong, Huang, Biao, Xue, Shaolong, U, Kin Pong, Tsang, Lai Ling, Zhang, Xiaohu, Li, Gang, Jiang, Xiaohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359252/ https://www.ncbi.nlm.nih.gov/pubmed/32660632 http://dx.doi.org/10.1186/s13287-020-01798-1

Ejemplares similares

Crosstalk of Hedgehog and mTORC1 Pathways
por: Larsen, Lasse Jonsgaard, et al.
Publicado: (2020)

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
por: Wang, Fangjie, et al.
Publicado: (2018)

Dysregulation of mTORC1/autophagy axis in senescence
por: Carroll, Bernadette, et al.
Publicado: (2017)

The crosstalk between MYC and mTORC1 during osteoclastogenesis
por: Bae, Seyeon, et al.
Publicado: (2022)

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma
por: Li, Ting, et al.
Publicado: (2020)

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization
por: Huang, Biao, et al.
Publicado: (2019)

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
por: Cadena Sandoval, Marti, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

The mTORC1-autophagy pathway is a target for senescent cell elimination
por: Kucheryavenko, Olena, et al.
Publicado: (2019)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1
por: Du, Heng, et al.
Publicado: (2023)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Reciprocal Regulation between Primary Cilia and mTORC1
por: Lai, Yandong, et al.
Publicado: (2020)

Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis
por: Gong, Sa, et al.
Publicado: (2023)

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)
por: Leontieva, Olga V., et al.
Publicado: (2015)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis
por: Seo, Seung Un, et al.
Publicado: (2018)

Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
por: Werzowa, Johannes, et al.
Publicado: (2010)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
por: Burnett, G. Leslie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cljnq3s9f12kkqdasbec8l0p8a