Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

BACKGROUND: Meningococcal meningitis (MM) is a life-threatening disease associated with approximately 10% case fatality rates and neurological sequelae in 10–20% of the cases. Recently, we have shown that the matrix metalloproteinase (MMP) inhibitor BB-94 reduced brain injury in a mouse model of MM....

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Detalles Bibliográficos
Autores principales: Ricci, Susanna, Grandgirard, Denis, Masouris, Ilias, Braccini, Tiziana, Pozzi, Gianni, Oggioni, Marco R., Koedel, Uwe, Leib, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359289/
https://www.ncbi.nlm.nih.gov/pubmed/32660552
http://dx.doi.org/10.1186/s12879-020-05226-w

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