High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

CRISPR-based genetic screening has revolutionized cancer drug target discovery, yet reliable, multiplex gene editing to reveal synergies between gene targets remains a major challenge. Here, we present a simple and robust CRISPR-Cas12a-based approach for combinatorial genetic screening in cancer cel...

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Detalles Bibliográficos
Autores principales: Gier, Rodrigo A., Budinich, Krista A., Evitt, Niklaus H., Cao, Zhendong, Freilich, Elizabeth S., Chen, Qingzhou, Qi, Jun, Lan, Yemin, Kohli, Rahul M., Shi, Junwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359328/
https://www.ncbi.nlm.nih.gov/pubmed/32661245
http://dx.doi.org/10.1038/s41467-020-17209-1

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