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Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report

BACKGROUND: Peritoneal carcinoma is a rare disease that is diagnosed and treated in a manner similar to ovarian cancer. In most cases, the histological type is serous carcinoma, and chemotherapy is effective. However, there are a few case reports of mucinous peritoneal carcinoma. We inferred the his...

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Autores principales: Nagao, Sachiko, Matsuura, Motoki, Tamate, Masato, Sugita, Shintaro, Saito, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359487/
https://www.ncbi.nlm.nih.gov/pubmed/32660614
http://dx.doi.org/10.1186/s13256-020-02435-4
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author Nagao, Sachiko
Matsuura, Motoki
Tamate, Masato
Sugita, Shintaro
Saito, Tsuyoshi
author_facet Nagao, Sachiko
Matsuura, Motoki
Tamate, Masato
Sugita, Shintaro
Saito, Tsuyoshi
author_sort Nagao, Sachiko
collection PubMed
description BACKGROUND: Peritoneal carcinoma is a rare disease that is diagnosed and treated in a manner similar to ovarian cancer. In most cases, the histological type is serous carcinoma, and chemotherapy is effective. However, there are a few case reports of mucinous peritoneal carcinoma. We inferred the histological type before surgery using an ascites cell block sample, which was useful for determining the treatment plan. CASE PRESENTATION: Our patient was a 60-year-old Japanese woman. She presented with a feeling of fullness in the abdomen. A computed tomographic scan showed a large quantity of ascitic fluid and thickening of the greater omentum, as well as thickening of the peritoneum at the pouch of Douglas and diaphragm. Hence, peritoneal carcinoma was suspected. The tumor markers carcinoembryonic antigen, cancer antigen 19-9, and cancer antigen 125 were all increased, and no malignant findings were observed in the uterus or ovaries. Cells suggestive of carcinoma were found in the ascitic fluid, and immunostaining by the cell block method suggested the possibility of mucinous carcinoma. The preoperative chemotherapy strategy was changed to short courses, and tumor reduction surgery was planned. Similar to the suspicion before surgery, the pathology results indicated mucinous carcinoma, and the therapeutic effect of chemotherapy was grade 0. CONCLUSIONS: Determining whether peritoneal carcinoma is serous carcinoma is important for therapy and prognostic prediction. In this case, we encountered a patient for whom surgery was chosen because of drug therapy resistance inferred through histological type estimation using the cell block method. Inferring the histological type by cell block preparation is useful for diagnosis and treatment selection.
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spelling pubmed-73594872020-07-17 Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report Nagao, Sachiko Matsuura, Motoki Tamate, Masato Sugita, Shintaro Saito, Tsuyoshi J Med Case Rep Case Report BACKGROUND: Peritoneal carcinoma is a rare disease that is diagnosed and treated in a manner similar to ovarian cancer. In most cases, the histological type is serous carcinoma, and chemotherapy is effective. However, there are a few case reports of mucinous peritoneal carcinoma. We inferred the histological type before surgery using an ascites cell block sample, which was useful for determining the treatment plan. CASE PRESENTATION: Our patient was a 60-year-old Japanese woman. She presented with a feeling of fullness in the abdomen. A computed tomographic scan showed a large quantity of ascitic fluid and thickening of the greater omentum, as well as thickening of the peritoneum at the pouch of Douglas and diaphragm. Hence, peritoneal carcinoma was suspected. The tumor markers carcinoembryonic antigen, cancer antigen 19-9, and cancer antigen 125 were all increased, and no malignant findings were observed in the uterus or ovaries. Cells suggestive of carcinoma were found in the ascitic fluid, and immunostaining by the cell block method suggested the possibility of mucinous carcinoma. The preoperative chemotherapy strategy was changed to short courses, and tumor reduction surgery was planned. Similar to the suspicion before surgery, the pathology results indicated mucinous carcinoma, and the therapeutic effect of chemotherapy was grade 0. CONCLUSIONS: Determining whether peritoneal carcinoma is serous carcinoma is important for therapy and prognostic prediction. In this case, we encountered a patient for whom surgery was chosen because of drug therapy resistance inferred through histological type estimation using the cell block method. Inferring the histological type by cell block preparation is useful for diagnosis and treatment selection. BioMed Central 2020-07-14 /pmc/articles/PMC7359487/ /pubmed/32660614 http://dx.doi.org/10.1186/s13256-020-02435-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Nagao, Sachiko
Matsuura, Motoki
Tamate, Masato
Sugita, Shintaro
Saito, Tsuyoshi
Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
title Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
title_full Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
title_fullStr Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
title_full_unstemmed Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
title_short Mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
title_sort mucinous carcinoma originating in the peritoneum diagnosed by an ascites cell block: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359487/
https://www.ncbi.nlm.nih.gov/pubmed/32660614
http://dx.doi.org/10.1186/s13256-020-02435-4
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