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SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques

CD4 T follicular helper (T(fh)) cells are important for the generation of long-lasting and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T(fh) cells and stimulates the germinal center response is an important question as we investigate vacci...

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Detalles Bibliográficos
Autores principales: Elizaldi, Sonny R., Lakshmanappa, Yashavanth Shaan, Roh, Jamin W., Schmidt, Brian A., Carroll, Timothy D., Weaver, Kourtney D., Smith, Justin C., Deere, Jesse D., Dutra, Joseph, Stone, Mars, Sammak, Rebecca Lee, Olstad, Katherine J., Reader, J. Rachel, Ma, Zhong-Min, Nguyen, Nancy K., Watanabe, Jennifer, Usachaenko, Jodie, Immareddy, Ramya, Yee, JoAnn L., Weiskopf, Daniela, Sette, Alessandro, Hartigan-O’Connor, Dennis, McSorley, Stephen J., Morrison, John H., Tran, Nam K., Simmons, Graham, Busch, Michael P, Kozlowski, Pamela A., Van Rompay, Koen K.A., Miller, Christopher J., Iyer, Smita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359530/
https://www.ncbi.nlm.nih.gov/pubmed/32676606
http://dx.doi.org/10.1101/2020.07.07.191007