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Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil

Infection by the protozoan Toxoplasma gondii during pregnancy demands greater attention from the health authorities due to the risk of placental transmission, which can have devastating consequences to the foetus and newborn. This study was conducted in a high-risk prenatal care outpatient clinic of...

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Autores principales: Evangelista, Fernanda Ferreira, Mantelo, Francini Martini, de Lima, Keller Karla, Marchioro, Ariella Andrade, Beletini, Lucimara Fátima, de Souza, Amanda Hinobu, Santana, Priscila Laet, Riedo, Cristiane de Oliveira, Higa, Lourenço Tsunetomi, Guilherme, Ana Lúcia Falavigna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359740/
https://www.ncbi.nlm.nih.gov/pubmed/32667393
http://dx.doi.org/10.1590/S1678-9946202062046
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author Evangelista, Fernanda Ferreira
Mantelo, Francini Martini
de Lima, Keller Karla
Marchioro, Ariella Andrade
Beletini, Lucimara Fátima
de Souza, Amanda Hinobu
Santana, Priscila Laet
Riedo, Cristiane de Oliveira
Higa, Lourenço Tsunetomi
Guilherme, Ana Lúcia Falavigna
author_facet Evangelista, Fernanda Ferreira
Mantelo, Francini Martini
de Lima, Keller Karla
Marchioro, Ariella Andrade
Beletini, Lucimara Fátima
de Souza, Amanda Hinobu
Santana, Priscila Laet
Riedo, Cristiane de Oliveira
Higa, Lourenço Tsunetomi
Guilherme, Ana Lúcia Falavigna
author_sort Evangelista, Fernanda Ferreira
collection PubMed
description Infection by the protozoan Toxoplasma gondii during pregnancy demands greater attention from the health authorities due to the risk of placental transmission, which can have devastating consequences to the foetus and newborn. This study was conducted in a high-risk prenatal care outpatient clinic of a university teaching hospital. Pregnant women screened for specific IgM and IgG anti -T. gondii, attended from January 2009 to August 2018 were included. From 530 suspected patients, 218 were followed up and they presented positive IgM and IgG anti- T. gondii. From these patients, 83 (38.0%) had low IgG avidity, 39 (18%) seroconverted in the second or third trimester of pregnancy, 19 (8.7%) had no avidity test, 69 (31.6%) had high IgG avidity after 16 weeks of gestation, five had recurrent chorioretinitis (2.2%) and three (1.3%) were seropositive to HIV. Complementary diagnoses were made in 30/48 (62.5%) of the patients revealing the presence of specific IgA antibodies raised to T. gondii; 3/63 (4.8%) peripheral blood samples and 1/57 (1.8%) amniotic fluid sample. There were eight foetal deaths, one case of neonatal hepatomegaly and one case of T. gondii DNA detected in a peripheral blood sample. Of the 139 newborn deliveries at the teaching hospital, there was a 38% loss of follow-up. The prevalence of congenital toxoplasmosis was 1.2 cases/1,000 live births in this study area, according to the retrospective survey of cases. Prenatal treatment may have helped to reduce the risk of vertical transmission.
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spelling pubmed-73597402020-07-21 Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil Evangelista, Fernanda Ferreira Mantelo, Francini Martini de Lima, Keller Karla Marchioro, Ariella Andrade Beletini, Lucimara Fátima de Souza, Amanda Hinobu Santana, Priscila Laet Riedo, Cristiane de Oliveira Higa, Lourenço Tsunetomi Guilherme, Ana Lúcia Falavigna Rev Inst Med Trop Sao Paulo Original Article Infection by the protozoan Toxoplasma gondii during pregnancy demands greater attention from the health authorities due to the risk of placental transmission, which can have devastating consequences to the foetus and newborn. This study was conducted in a high-risk prenatal care outpatient clinic of a university teaching hospital. Pregnant women screened for specific IgM and IgG anti -T. gondii, attended from January 2009 to August 2018 were included. From 530 suspected patients, 218 were followed up and they presented positive IgM and IgG anti- T. gondii. From these patients, 83 (38.0%) had low IgG avidity, 39 (18%) seroconverted in the second or third trimester of pregnancy, 19 (8.7%) had no avidity test, 69 (31.6%) had high IgG avidity after 16 weeks of gestation, five had recurrent chorioretinitis (2.2%) and three (1.3%) were seropositive to HIV. Complementary diagnoses were made in 30/48 (62.5%) of the patients revealing the presence of specific IgA antibodies raised to T. gondii; 3/63 (4.8%) peripheral blood samples and 1/57 (1.8%) amniotic fluid sample. There were eight foetal deaths, one case of neonatal hepatomegaly and one case of T. gondii DNA detected in a peripheral blood sample. Of the 139 newborn deliveries at the teaching hospital, there was a 38% loss of follow-up. The prevalence of congenital toxoplasmosis was 1.2 cases/1,000 live births in this study area, according to the retrospective survey of cases. Prenatal treatment may have helped to reduce the risk of vertical transmission. Instituto de Medicina Tropical 2020-07-13 /pmc/articles/PMC7359740/ /pubmed/32667393 http://dx.doi.org/10.1590/S1678-9946202062046 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Evangelista, Fernanda Ferreira
Mantelo, Francini Martini
de Lima, Keller Karla
Marchioro, Ariella Andrade
Beletini, Lucimara Fátima
de Souza, Amanda Hinobu
Santana, Priscila Laet
Riedo, Cristiane de Oliveira
Higa, Lourenço Tsunetomi
Guilherme, Ana Lúcia Falavigna
Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil
title Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil
title_full Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil
title_fullStr Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil
title_full_unstemmed Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil
title_short Prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in Southern Brazil
title_sort prospective evalution of pregnant women with suspected acute toxoplasmosis treated in a reference prenatal care clinic at a university teaching hospital in southern brazil
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359740/
https://www.ncbi.nlm.nih.gov/pubmed/32667393
http://dx.doi.org/10.1590/S1678-9946202062046
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