Cargando…

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Understanding the root causes of autoimmune diseases is hampered by the inability to access relevant human tissues and identify the time of disease onset. To examine the interaction of immune cells and their cellular targets in type 1 diabetes, we differentiated human induced pluripotent stem cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leite, Nayara C., Sintov, Elad, Meissner, Torsten B., Brehm, Michael A., Greiner, Dale L., Harlan, David M., Melton, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359783/ https://www.ncbi.nlm.nih.gov/pubmed/32668238 http://dx.doi.org/10.1016/j.celrep.2020.107894

Ejemplares similares

Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro
por: Leite, Nayara C., et al.
Publicado: (2022)

Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
por: Gerace, Dario, et al.
Publicado: (2023)

An improved ScoreCard to assess the differentiation potential of human pluripotent stem cells
por: Tsankov, Alexander M., et al.
Publicado: (2015)

Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets
por: Sintov, Elad, et al.
Publicado: (2022)

Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
por: Kooreman, Nigel G., et al.
Publicado: (2017)

Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro
por: Sintov, Elad, et al.
Publicado: (2015)

A simple tool to improve pluripotent stem cell differentiation
por: Chetty, Sundari, et al.
Publicado: (2013)

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation
por: Chetty, Sundari, et al.
Publicado: (2015)

Genome Editing and Human Pluripotent Stem Cell Technologies for in vitro Monogenic Diabetes Modeling
por: Dabi, Yosef Tsegaye, et al.
Publicado: (2022)

Monogenic Diabetes Modeling: In Vitro Pancreatic Differentiation From Human Pluripotent Stem Cells Gains Momentum
por: Burgos, Juan Ignacio, et al.
Publicado: (2021)

In Vitro Culture-Induced Pluripotency of Human Spermatogonial Stem Cells
por: Lim, Jung Jin, et al.
Publicado: (2013)

Generation of improved humanized mouse models for human infectious diseases
por: Brehm, Michael A., et al.
Publicado: (2014)

Efficient Generation of NKX6-1(+) Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines
por: Nostro, M. Cristina, et al.
Publicado: (2015)

Proteomic and Transcriptional Profiles of Human Stem Cell-Derived β Cells Following Enteroviral Challenge
por: Nyalwidhe, Julius O., et al.
Publicado: (2020)

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
por: Spence, Jason R., et al.
Publicado: (2010)

Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro
por: Russ, Holger A., et al.
Publicado: (2011)

Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice
por: Lee, Jinhee, et al.
Publicado: (2013)

Viral Infection of Engrafted Human Islets Leads to Diabetes
por: Gallagher, Glen R., et al.
Publicado: (2015)

Salicylate Prevents Virus-Induced Type 1 Diabetes in the BBDR Rat
por: Yang, Chaoxing, et al.
Publicado: (2013)

In vitro generation of human pluripotent stem cell derived lung organoids
por: Dye, Briana R, et al.
Publicado: (2015)

Functional Enterospheres Derived In Vitro from Human Pluripotent Stem Cells
por: Nadkarni, Rohan R., et al.
Publicado: (2017)

Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells
por: Srivastava, Pallavi, et al.
Publicado: (2022)

Human Pluripotent Stem Cells to Model Islet Defects in Diabetes
por: Balboa, Diego, et al.
Publicado: (2021)

Toward Precision Medicine with Human Pluripotent Stem Cells for Diabetes
por: Memon, Bushra, et al.
Publicado: (2022)

Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology
por: Joshi, Kriti, et al.
Publicado: (2021)

Generation of stem cell-derived β-cells from patients with type 1 diabetes
por: Millman, Jeffrey R., et al.
Publicado: (2016)

Nutritional requirements of human induced pluripotent stem cells
por: Lyra-Leite, Davi M., et al.
Publicado: (2023)

Genome scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes
por: Cai, Erica P., et al.
Publicado: (2020)

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes
por: Millman, Jeffrey R., et al.
Publicado: (2016)

In Vitro Modeling of Human Germ Cell Development Using Pluripotent Stem Cells
por: Zhao, Yuncheng, et al.
Publicado: (2018)

Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells
por: Hwang, Young Sun, et al.
Publicado: (2020)

Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells
por: Javaid, Muhammad Shahid, et al.
Publicado: (2022)

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays
por: Bouma, Marga J., et al.
Publicado: (2017)

Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
por: Meissner, Torsten B., et al.
Publicado: (2022)

Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses In Vitro and In Vivo
por: Shamis, Yulia, et al.
Publicado: (2013)

Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells
por: Rohani, Leili, et al.
Publicado: (2020)

Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons In Vitro
por: Gunewardene, Niliksha, et al.
Publicado: (2016)

Generation of hypothalamic neural stem cell-like cells in vitro from human pluripotent stem cells
por: Miwata, Tsutomu, et al.
Publicado: (2023)

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells
por: Livesey, Matthew R., et al.
Publicado: (2015)

Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro
por: Galiakberova, Adelya A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8nhkceghsotljbnnpekkb3n4r8