Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1

INTRODUCTION: EVI1 (MECOM)-positive acute myeloid leukemia (AML) cells have shown in vitro sensitivity to all-trans-retinoic acid (ATRA) by inducing differentiation, cell death, and decreased leukemic engraftment. METHODS: In this pilot study, we investigated the response to ATRA in 13 high-risk AML...

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Autores principales: Paubelle, Etienne, Plesa, Adriana, Hayette, Sandrine, Elhamri, Mohamed, Zylbersztejn, Florence, Hermine, Olivier, Salles, Gilles, Thomas, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359977/
https://www.ncbi.nlm.nih.gov/pubmed/32699982
http://dx.doi.org/10.1007/s40487-019-0095-9
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author Paubelle, Etienne
Plesa, Adriana
Hayette, Sandrine
Elhamri, Mohamed
Zylbersztejn, Florence
Hermine, Olivier
Salles, Gilles
Thomas, Xavier
author_facet Paubelle, Etienne
Plesa, Adriana
Hayette, Sandrine
Elhamri, Mohamed
Zylbersztejn, Florence
Hermine, Olivier
Salles, Gilles
Thomas, Xavier
author_sort Paubelle, Etienne
collection PubMed
description INTRODUCTION: EVI1 (MECOM)-positive acute myeloid leukemia (AML) cells have shown in vitro sensitivity to all-trans-retinoic acid (ATRA) by inducing differentiation, cell death, and decreased leukemic engraftment. METHODS: In this pilot study, we investigated the response to ATRA in 13 high-risk AML patients with overexpression of EVI1. RESULTS: Seven of the 13 patients (53.8%) achieved complete remission (CR), and response can be combined with a decreased of the leukemia stem cell pool. CONCLUSION: These primary results tend to confirm in vitro results and suggest that addition of ATRA might be of benefit in the treatment of patients with EVI1-positive AML.
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spelling pubmed-73599772020-07-20 Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1 Paubelle, Etienne Plesa, Adriana Hayette, Sandrine Elhamri, Mohamed Zylbersztejn, Florence Hermine, Olivier Salles, Gilles Thomas, Xavier Oncol Ther Original Research INTRODUCTION: EVI1 (MECOM)-positive acute myeloid leukemia (AML) cells have shown in vitro sensitivity to all-trans-retinoic acid (ATRA) by inducing differentiation, cell death, and decreased leukemic engraftment. METHODS: In this pilot study, we investigated the response to ATRA in 13 high-risk AML patients with overexpression of EVI1. RESULTS: Seven of the 13 patients (53.8%) achieved complete remission (CR), and response can be combined with a decreased of the leukemia stem cell pool. CONCLUSION: These primary results tend to confirm in vitro results and suggest that addition of ATRA might be of benefit in the treatment of patients with EVI1-positive AML. Springer Healthcare 2019-05-22 /pmc/articles/PMC7359977/ /pubmed/32699982 http://dx.doi.org/10.1007/s40487-019-0095-9 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Paubelle, Etienne
Plesa, Adriana
Hayette, Sandrine
Elhamri, Mohamed
Zylbersztejn, Florence
Hermine, Olivier
Salles, Gilles
Thomas, Xavier
Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1
title Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1
title_full Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1
title_fullStr Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1
title_full_unstemmed Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1
title_short Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1
title_sort efficacy of all-trans-retinoic acid in high-risk acute myeloid leukemia with overexpression of evi1
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359977/
https://www.ncbi.nlm.nih.gov/pubmed/32699982
http://dx.doi.org/10.1007/s40487-019-0095-9
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