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Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia
Neurotoxicity is one of the most common side effects of oxaliplatin-based therapy. Most patients who receive at least 3–4 months of treatment suffer from peripheral sensory neurotoxicity (PSN), characterised by the loss or impairment of tactile and proprioceptive sensory function. Motor impairment,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360012/ https://www.ncbi.nlm.nih.gov/pubmed/32700068 http://dx.doi.org/10.1007/s40487-019-00102-3 |
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author | Giampieri, Riccardo Maccaroni, Elena Sotte, Valeria Baleani, Maria G. Meletani, Tania Giglio, Enrica Pecci, Federica Bittoni, Alessandro Lanese, Andrea Cantini, Luca Mentrasti, Giulia Lucarelli, Alessandra Berardi, Rossana |
author_facet | Giampieri, Riccardo Maccaroni, Elena Sotte, Valeria Baleani, Maria G. Meletani, Tania Giglio, Enrica Pecci, Federica Bittoni, Alessandro Lanese, Andrea Cantini, Luca Mentrasti, Giulia Lucarelli, Alessandra Berardi, Rossana |
author_sort | Giampieri, Riccardo |
collection | PubMed |
description | Neurotoxicity is one of the most common side effects of oxaliplatin-based therapy. Most patients who receive at least 3–4 months of treatment suffer from peripheral sensory neurotoxicity (PSN), characterised by the loss or impairment of tactile and proprioceptive sensory function. Motor impairment, such as muscle weakness or palsy, has been rarely described, and the physiopathology of PSN, as well as the motor symptoms due to oxaliplatin-based treatment, are not adequately understood. Here we report the case of a patient who experienced severe acute peripheral motor neuropathy as a side effect of oxaliplatin-based treatment. We also review other cases of PSN published in the literature and suggest a novel hypothesis on the physiopathology of this particular event. Take-away lessons: Not all of the neurological symptoms observed during oxaliplatin-based treatment can be traced back directly to the oxaliplatin itself, and other factors, such as electrolyte imbalances, may contribute to the symptoms. Patients with gastro-intestinal malignancies are the patients most affected by neurotoxicity due to the side effects of chemotherapy and the disease itself. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40487-019-00102-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7360012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-73600122020-07-20 Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia Giampieri, Riccardo Maccaroni, Elena Sotte, Valeria Baleani, Maria G. Meletani, Tania Giglio, Enrica Pecci, Federica Bittoni, Alessandro Lanese, Andrea Cantini, Luca Mentrasti, Giulia Lucarelli, Alessandra Berardi, Rossana Oncol Ther Case Report Neurotoxicity is one of the most common side effects of oxaliplatin-based therapy. Most patients who receive at least 3–4 months of treatment suffer from peripheral sensory neurotoxicity (PSN), characterised by the loss or impairment of tactile and proprioceptive sensory function. Motor impairment, such as muscle weakness or palsy, has been rarely described, and the physiopathology of PSN, as well as the motor symptoms due to oxaliplatin-based treatment, are not adequately understood. Here we report the case of a patient who experienced severe acute peripheral motor neuropathy as a side effect of oxaliplatin-based treatment. We also review other cases of PSN published in the literature and suggest a novel hypothesis on the physiopathology of this particular event. Take-away lessons: Not all of the neurological symptoms observed during oxaliplatin-based treatment can be traced back directly to the oxaliplatin itself, and other factors, such as electrolyte imbalances, may contribute to the symptoms. Patients with gastro-intestinal malignancies are the patients most affected by neurotoxicity due to the side effects of chemotherapy and the disease itself. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40487-019-00102-3) contains supplementary material, which is available to authorized users. Springer Healthcare 2019-12-05 /pmc/articles/PMC7360012/ /pubmed/32700068 http://dx.doi.org/10.1007/s40487-019-00102-3 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Giampieri, Riccardo Maccaroni, Elena Sotte, Valeria Baleani, Maria G. Meletani, Tania Giglio, Enrica Pecci, Federica Bittoni, Alessandro Lanese, Andrea Cantini, Luca Mentrasti, Giulia Lucarelli, Alessandra Berardi, Rossana Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia |
title | Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia |
title_full | Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia |
title_fullStr | Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia |
title_full_unstemmed | Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia |
title_short | Acute Peripheral Motor Neuropathy Induced by Oxaliplatin-Correlated Hypokalaemia |
title_sort | acute peripheral motor neuropathy induced by oxaliplatin-correlated hypokalaemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360012/ https://www.ncbi.nlm.nih.gov/pubmed/32700068 http://dx.doi.org/10.1007/s40487-019-00102-3 |
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