Cargando…

Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation

Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapi...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnston, Simon J., Cheung, Kwok-Leung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360014/
https://www.ncbi.nlm.nih.gov/pubmed/32700026
http://dx.doi.org/10.1007/s40487-018-0062-x
_version_ 1783559153534369792
author Johnston, Simon J.
Cheung, Kwok-Leung
author_facet Johnston, Simon J.
Cheung, Kwok-Leung
author_sort Johnston, Simon J.
collection PubMed
description Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario.
format Online
Article
Text
id pubmed-7360014
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-73600142020-07-20 Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation Johnston, Simon J. Cheung, Kwok-Leung Oncol Ther Review Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited in combination with established endocrine therapies to maximise efficacy. However, clinicians must balance this gain against the risk to patients of increased side effects with combination therapies. This article provides a succinct outline of the principles of hormonal manipulation in breast cancer, alongside the key evidence that underpins current clinical practice. As the role of endocrine therapy in breast cancer continues to expand, the challenge is to interpret the data and select the optimal strategy for a given clinical scenario. Springer Healthcare 2018-07-10 /pmc/articles/PMC7360014/ /pubmed/32700026 http://dx.doi.org/10.1007/s40487-018-0062-x Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Johnston, Simon J.
Cheung, Kwok-Leung
Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation
title Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation
title_full Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation
title_fullStr Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation
title_full_unstemmed Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation
title_short Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation
title_sort endocrine therapy for breast cancer: a model of hormonal manipulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360014/
https://www.ncbi.nlm.nih.gov/pubmed/32700026
http://dx.doi.org/10.1007/s40487-018-0062-x
work_keys_str_mv AT johnstonsimonj endocrinetherapyforbreastcanceramodelofhormonalmanipulation
AT cheungkwokleung endocrinetherapyforbreastcanceramodelofhormonalmanipulation