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Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection

We investigated the association between age, duration of clinical symptoms and viral shedding in outpatient children infected with respiratory syncytial virus (RSV) in Japan. METHODS: Outpatients younger than 2 years of age, with suspected RSV infection between 2014 and 2018, were enrolled in the st...

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Autores principales: Utsunomiya, Takeshi, Hibino, Akinobu, Taniguchi, Kiyosu, Nagai, Takao, Saito, Naruo, Tanabe, Ikumi, Odagiri, Takashi, Shobugawa, Yugo, Kaneko, Akira, Saito, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360094/
https://www.ncbi.nlm.nih.gov/pubmed/32101910
http://dx.doi.org/10.1097/INF.0000000000002626
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author Utsunomiya, Takeshi
Hibino, Akinobu
Taniguchi, Kiyosu
Nagai, Takao
Saito, Naruo
Tanabe, Ikumi
Odagiri, Takashi
Shobugawa, Yugo
Kaneko, Akira
Saito, Reiko
author_facet Utsunomiya, Takeshi
Hibino, Akinobu
Taniguchi, Kiyosu
Nagai, Takao
Saito, Naruo
Tanabe, Ikumi
Odagiri, Takashi
Shobugawa, Yugo
Kaneko, Akira
Saito, Reiko
author_sort Utsunomiya, Takeshi
collection PubMed
description We investigated the association between age, duration of clinical symptoms and viral shedding in outpatient children infected with respiratory syncytial virus (RSV) in Japan. METHODS: Outpatients younger than 2 years of age, with suspected RSV infection between 2014 and 2018, were enrolled in the study. Following informed consent, nasal samples were collected at first and second clinic visits (with 0–9 days gap). RSV-A or -B infection and viral load were determined by real-time polymerase chain reaction. Clinical symptoms were recorded at first clinic visit, and fever and symptoms were recorded at home for up to 8 days. Association between clinical symptoms and patient characteristics, such as age, sex and birth weight, were analyzed using ordered logistic regression analysis. The association between viral reduction and estimated shedding period was examined using linear regression analysis. RESULTS: Among the 205 cases enrolled in the study, no difference was found in patient characteristics between RSV-A and -B infection. Duration of fever was prolonged with increased age. Duration of rhinorrhea and cough was shorter in females than in males and in groups with birth weight ≥3 kg than in those with <2.5 kg. Daily viral reduction increased and estimated viral elimination period decreased with age. CONCLUSIONS: Fever duration was found to increase while viral shedding decreased with patient age.
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spelling pubmed-73600942020-08-05 Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection Utsunomiya, Takeshi Hibino, Akinobu Taniguchi, Kiyosu Nagai, Takao Saito, Naruo Tanabe, Ikumi Odagiri, Takashi Shobugawa, Yugo Kaneko, Akira Saito, Reiko Pediatr Infect Dis J Original Studies We investigated the association between age, duration of clinical symptoms and viral shedding in outpatient children infected with respiratory syncytial virus (RSV) in Japan. METHODS: Outpatients younger than 2 years of age, with suspected RSV infection between 2014 and 2018, were enrolled in the study. Following informed consent, nasal samples were collected at first and second clinic visits (with 0–9 days gap). RSV-A or -B infection and viral load were determined by real-time polymerase chain reaction. Clinical symptoms were recorded at first clinic visit, and fever and symptoms were recorded at home for up to 8 days. Association between clinical symptoms and patient characteristics, such as age, sex and birth weight, were analyzed using ordered logistic regression analysis. The association between viral reduction and estimated shedding period was examined using linear regression analysis. RESULTS: Among the 205 cases enrolled in the study, no difference was found in patient characteristics between RSV-A and -B infection. Duration of fever was prolonged with increased age. Duration of rhinorrhea and cough was shorter in females than in males and in groups with birth weight ≥3 kg than in those with <2.5 kg. Daily viral reduction increased and estimated viral elimination period decreased with age. CONCLUSIONS: Fever duration was found to increase while viral shedding decreased with patient age. Lippincott Williams & Wilkins 2020-02-24 2020-08 /pmc/articles/PMC7360094/ /pubmed/32101910 http://dx.doi.org/10.1097/INF.0000000000002626 Text en Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Studies
Utsunomiya, Takeshi
Hibino, Akinobu
Taniguchi, Kiyosu
Nagai, Takao
Saito, Naruo
Tanabe, Ikumi
Odagiri, Takashi
Shobugawa, Yugo
Kaneko, Akira
Saito, Reiko
Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection
title Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection
title_full Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection
title_fullStr Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection
title_full_unstemmed Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection
title_short Factors Contributing to Symptom Duration and Viral Reduction in Outpatient Children With Respiratory Syncytial Virus Infection
title_sort factors contributing to symptom duration and viral reduction in outpatient children with respiratory syncytial virus infection
topic Original Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360094/
https://www.ncbi.nlm.nih.gov/pubmed/32101910
http://dx.doi.org/10.1097/INF.0000000000002626
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