Cargando…
Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan
Among human immunodeficiency virus (HIV)–infected individuals, syphilis is an important sexually transmitted infection (STI), and repeat infections are common. Identifying risk factors for delineating the trends in repeat syphilis are essential for STI and HIV prevention. This study is to investigat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360277/ https://www.ncbi.nlm.nih.gov/pubmed/32664143 http://dx.doi.org/10.1097/MD.0000000000021132 |
_version_ | 1783559191276814336 |
---|---|
author | Lee, Nan-Yao Chen, Yen-Chin Liu, Hsiao-Ying Li, Chung-Yi Li, Chia-Wen Ko, Wen-Chien Ko, Nai-Ying |
author_facet | Lee, Nan-Yao Chen, Yen-Chin Liu, Hsiao-Ying Li, Chung-Yi Li, Chia-Wen Ko, Wen-Chien Ko, Nai-Ying |
author_sort | Lee, Nan-Yao |
collection | PubMed |
description | Among human immunodeficiency virus (HIV)–infected individuals, syphilis is an important sexually transmitted infection (STI), and repeat infections are common. Identifying risk factors for delineating the trends in repeat syphilis are essential for STI and HIV prevention. This study is to investigate the dynamic of the syphilis epidemic among HIV-infected patients and to identify the risk factors associated with repeat syphilis. A population-based cohort design was used to analyze claim data between January 2000 and December 2010 using the Taiwan National Health Insurance Research Database. The Poisson regression test was used to identify risk factors for repeat syphilis. Of 13,239 HIV-infected patients, annual syphilis screen tests have been performed in 4,907 (37.1%) of these patients. Syphilis has been diagnosed in 956 (19.5%) patients, and 524 (10.7%) had repeat syphilis. The annual trend in repeat syphilis showed a significant increase in the study period (β = 0.23, P < .001). Younger age (adjusted incidence rate ratio [aIRR] 1.43; 95% CI 1.11–1.86), male gender (aIRR 11.14, 95% CI 4.16–29.79), a history of STIs (aIRR 1.39, 95% CI 1.21–1.59) were independently associated with repeat syphilis. The retention in HIV care and adherence to antiretroviral therapy ≥85% ([aIRR] 0.77, 95% CI 0.61–0.98; P < .001) were associated with a reduced risk of repeat syphilis. The incidence of repeat syphilis increased during 11 years of follow-up. The screening of syphilis for early diagnosis and retention in HIV care with medication adherence should be encouraged to minimize the risk of repeat syphilis in the targeted population. |
format | Online Article Text |
id | pubmed-7360277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-73602772020-08-05 Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan Lee, Nan-Yao Chen, Yen-Chin Liu, Hsiao-Ying Li, Chung-Yi Li, Chia-Wen Ko, Wen-Chien Ko, Nai-Ying Medicine (Baltimore) 4850 Among human immunodeficiency virus (HIV)–infected individuals, syphilis is an important sexually transmitted infection (STI), and repeat infections are common. Identifying risk factors for delineating the trends in repeat syphilis are essential for STI and HIV prevention. This study is to investigate the dynamic of the syphilis epidemic among HIV-infected patients and to identify the risk factors associated with repeat syphilis. A population-based cohort design was used to analyze claim data between January 2000 and December 2010 using the Taiwan National Health Insurance Research Database. The Poisson regression test was used to identify risk factors for repeat syphilis. Of 13,239 HIV-infected patients, annual syphilis screen tests have been performed in 4,907 (37.1%) of these patients. Syphilis has been diagnosed in 956 (19.5%) patients, and 524 (10.7%) had repeat syphilis. The annual trend in repeat syphilis showed a significant increase in the study period (β = 0.23, P < .001). Younger age (adjusted incidence rate ratio [aIRR] 1.43; 95% CI 1.11–1.86), male gender (aIRR 11.14, 95% CI 4.16–29.79), a history of STIs (aIRR 1.39, 95% CI 1.21–1.59) were independently associated with repeat syphilis. The retention in HIV care and adherence to antiretroviral therapy ≥85% ([aIRR] 0.77, 95% CI 0.61–0.98; P < .001) were associated with a reduced risk of repeat syphilis. The incidence of repeat syphilis increased during 11 years of follow-up. The screening of syphilis for early diagnosis and retention in HIV care with medication adherence should be encouraged to minimize the risk of repeat syphilis in the targeted population. Wolters Kluwer Health 2020-07-10 /pmc/articles/PMC7360277/ /pubmed/32664143 http://dx.doi.org/10.1097/MD.0000000000021132 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 4850 Lee, Nan-Yao Chen, Yen-Chin Liu, Hsiao-Ying Li, Chung-Yi Li, Chia-Wen Ko, Wen-Chien Ko, Nai-Ying Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan |
title | Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan |
title_full | Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan |
title_fullStr | Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan |
title_full_unstemmed | Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan |
title_short | Increased repeat syphilis among HIV-infected patients: A nationwide population-based cohort study in Taiwan |
title_sort | increased repeat syphilis among hiv-infected patients: a nationwide population-based cohort study in taiwan |
topic | 4850 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360277/ https://www.ncbi.nlm.nih.gov/pubmed/32664143 http://dx.doi.org/10.1097/MD.0000000000021132 |
work_keys_str_mv | AT leenanyao increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan AT chenyenchin increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan AT liuhsiaoying increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan AT lichungyi increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan AT lichiawen increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan AT kowenchien increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan AT konaiying increasedrepeatsyphilisamonghivinfectedpatientsanationwidepopulationbasedcohortstudyintaiwan |