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Risk of psychiatric disorders among the surviving twins after a co-twin loss
Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a co-twin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age- and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360364/ https://www.ncbi.nlm.nih.gov/pubmed/32660693 http://dx.doi.org/10.7554/eLife.56860 |
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author | Song, Huan Larsson, Henrik Fang, Fang Almqvist, Catarina Pedersen, Nancy L Magnusson, Patrik KE Valdimarsdóttir, Unnur A |
author_facet | Song, Huan Larsson, Henrik Fang, Fang Almqvist, Catarina Pedersen, Nancy L Magnusson, Patrik KE Valdimarsdóttir, Unnur A |
author_sort | Song, Huan |
collection | PubMed |
description | Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a co-twin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age- and sex-matched non-bereaved twins. Compared to the non-bereaved twins, exposed twins were at increased risk of receiving a first diagnosis of psychiatric disorders (hazard ratio = 1.65, 95% confidence interval1.48–1.83), particularly during the first month after loss. Similarly, compared to non-twin full siblings, the relative risks were significantly increased after loss of monozygotic co-twin (2.45-fold), and loss of a dizygotic co-twin (1.29-fold), with higher HR observed with greater age gaps between twins and non-twin siblings. As dizygotic twins share equal genetic relatedness to the deceased twin as their full siblings, this pattern suggests that beyond the contribution of genetic factors, shared early life experiences and attachment contribute to the risk of psychiatric disorders among surviving twins after co-twin loss. |
format | Online Article Text |
id | pubmed-7360364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73603642020-07-15 Risk of psychiatric disorders among the surviving twins after a co-twin loss Song, Huan Larsson, Henrik Fang, Fang Almqvist, Catarina Pedersen, Nancy L Magnusson, Patrik KE Valdimarsdóttir, Unnur A eLife Epidemiology and Global Health Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a co-twin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age- and sex-matched non-bereaved twins. Compared to the non-bereaved twins, exposed twins were at increased risk of receiving a first diagnosis of psychiatric disorders (hazard ratio = 1.65, 95% confidence interval1.48–1.83), particularly during the first month after loss. Similarly, compared to non-twin full siblings, the relative risks were significantly increased after loss of monozygotic co-twin (2.45-fold), and loss of a dizygotic co-twin (1.29-fold), with higher HR observed with greater age gaps between twins and non-twin siblings. As dizygotic twins share equal genetic relatedness to the deceased twin as their full siblings, this pattern suggests that beyond the contribution of genetic factors, shared early life experiences and attachment contribute to the risk of psychiatric disorders among surviving twins after co-twin loss. eLife Sciences Publications, Ltd 2020-07-14 /pmc/articles/PMC7360364/ /pubmed/32660693 http://dx.doi.org/10.7554/eLife.56860 Text en © 2020, Song et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Epidemiology and Global Health Song, Huan Larsson, Henrik Fang, Fang Almqvist, Catarina Pedersen, Nancy L Magnusson, Patrik KE Valdimarsdóttir, Unnur A Risk of psychiatric disorders among the surviving twins after a co-twin loss |
title | Risk of psychiatric disorders among the surviving twins after a co-twin loss |
title_full | Risk of psychiatric disorders among the surviving twins after a co-twin loss |
title_fullStr | Risk of psychiatric disorders among the surviving twins after a co-twin loss |
title_full_unstemmed | Risk of psychiatric disorders among the surviving twins after a co-twin loss |
title_short | Risk of psychiatric disorders among the surviving twins after a co-twin loss |
title_sort | risk of psychiatric disorders among the surviving twins after a co-twin loss |
topic | Epidemiology and Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360364/ https://www.ncbi.nlm.nih.gov/pubmed/32660693 http://dx.doi.org/10.7554/eLife.56860 |
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