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Risk of psychiatric disorders among the surviving twins after a co-twin loss

Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a co-twin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age- and...

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Autores principales: Song, Huan, Larsson, Henrik, Fang, Fang, Almqvist, Catarina, Pedersen, Nancy L, Magnusson, Patrik KE, Valdimarsdóttir, Unnur A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360364/
https://www.ncbi.nlm.nih.gov/pubmed/32660693
http://dx.doi.org/10.7554/eLife.56860
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author Song, Huan
Larsson, Henrik
Fang, Fang
Almqvist, Catarina
Pedersen, Nancy L
Magnusson, Patrik KE
Valdimarsdóttir, Unnur A
author_facet Song, Huan
Larsson, Henrik
Fang, Fang
Almqvist, Catarina
Pedersen, Nancy L
Magnusson, Patrik KE
Valdimarsdóttir, Unnur A
author_sort Song, Huan
collection PubMed
description Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a co-twin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age- and sex-matched non-bereaved twins. Compared to the non-bereaved twins, exposed twins were at increased risk of receiving a first diagnosis of psychiatric disorders (hazard ratio = 1.65, 95% confidence interval1.48–1.83), particularly during the first month after loss. Similarly, compared to non-twin full siblings, the relative risks were significantly increased after loss of monozygotic co-twin (2.45-fold), and loss of a dizygotic co-twin (1.29-fold), with higher HR observed with greater age gaps between twins and non-twin siblings. As dizygotic twins share equal genetic relatedness to the deceased twin as their full siblings, this pattern suggests that beyond the contribution of genetic factors, shared early life experiences and attachment contribute to the risk of psychiatric disorders among surviving twins after co-twin loss.
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spelling pubmed-73603642020-07-15 Risk of psychiatric disorders among the surviving twins after a co-twin loss Song, Huan Larsson, Henrik Fang, Fang Almqvist, Catarina Pedersen, Nancy L Magnusson, Patrik KE Valdimarsdóttir, Unnur A eLife Epidemiology and Global Health Losing a co-twin by death is a severely stressful event yet with unknown impact on the surviving twin’s risk of psychiatric disorders. We identified all Swedish-born twins who lost a co-twin by death between 1973 and 2013 (n = 4,528), their 4939 non-twin full siblings, together with 22,640 age- and sex-matched non-bereaved twins. Compared to the non-bereaved twins, exposed twins were at increased risk of receiving a first diagnosis of psychiatric disorders (hazard ratio = 1.65, 95% confidence interval1.48–1.83), particularly during the first month after loss. Similarly, compared to non-twin full siblings, the relative risks were significantly increased after loss of monozygotic co-twin (2.45-fold), and loss of a dizygotic co-twin (1.29-fold), with higher HR observed with greater age gaps between twins and non-twin siblings. As dizygotic twins share equal genetic relatedness to the deceased twin as their full siblings, this pattern suggests that beyond the contribution of genetic factors, shared early life experiences and attachment contribute to the risk of psychiatric disorders among surviving twins after co-twin loss. eLife Sciences Publications, Ltd 2020-07-14 /pmc/articles/PMC7360364/ /pubmed/32660693 http://dx.doi.org/10.7554/eLife.56860 Text en © 2020, Song et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Epidemiology and Global Health
Song, Huan
Larsson, Henrik
Fang, Fang
Almqvist, Catarina
Pedersen, Nancy L
Magnusson, Patrik KE
Valdimarsdóttir, Unnur A
Risk of psychiatric disorders among the surviving twins after a co-twin loss
title Risk of psychiatric disorders among the surviving twins after a co-twin loss
title_full Risk of psychiatric disorders among the surviving twins after a co-twin loss
title_fullStr Risk of psychiatric disorders among the surviving twins after a co-twin loss
title_full_unstemmed Risk of psychiatric disorders among the surviving twins after a co-twin loss
title_short Risk of psychiatric disorders among the surviving twins after a co-twin loss
title_sort risk of psychiatric disorders among the surviving twins after a co-twin loss
topic Epidemiology and Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360364/
https://www.ncbi.nlm.nih.gov/pubmed/32660693
http://dx.doi.org/10.7554/eLife.56860
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