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Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease

We are gradually becoming aware that there is more to Parkinson's disease (PD) than meets the eye. Accumulating evidence has unveiled a disease complexity that has not (yet) been incorporated into ongoing efforts aimed at slowing, halting or reversing the course of PD, likely underlying their l...

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Autores principales: Poortvliet, Peter C., O'Maley, Karen, Silburn, Peter A., Mellick, George D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360677/
https://www.ncbi.nlm.nih.gov/pubmed/32733372
http://dx.doi.org/10.3389/fneur.2020.00686
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author Poortvliet, Peter C.
O'Maley, Karen
Silburn, Peter A.
Mellick, George D.
author_facet Poortvliet, Peter C.
O'Maley, Karen
Silburn, Peter A.
Mellick, George D.
author_sort Poortvliet, Peter C.
collection PubMed
description We are gradually becoming aware that there is more to Parkinson's disease (PD) than meets the eye. Accumulating evidence has unveiled a disease complexity that has not (yet) been incorporated into ongoing efforts aimed at slowing, halting or reversing the course of PD, likely underlying their lack of success. There is a substantial latency between the actual onset of PD pathology and our ability to confirm diagnosis, during which accumulating structural and functional damage might be too advanced for effective modification or protection. Identification at the earliest stages of the disease course in the absence of Parkinsonism is crucial if we are to intervene when it matters most. Prognostic and therapeutic inferences can only be successful if we are able to accurately predict who is at risk for developing PD and if we can differentiate amongst the considerable clinicopathologic diversity. Biomarkers can greatly improve our identification and differentiation abilities if we are able to disentangle cause and effect.
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spelling pubmed-73606772020-07-29 Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease Poortvliet, Peter C. O'Maley, Karen Silburn, Peter A. Mellick, George D. Front Neurol Neurology We are gradually becoming aware that there is more to Parkinson's disease (PD) than meets the eye. Accumulating evidence has unveiled a disease complexity that has not (yet) been incorporated into ongoing efforts aimed at slowing, halting or reversing the course of PD, likely underlying their lack of success. There is a substantial latency between the actual onset of PD pathology and our ability to confirm diagnosis, during which accumulating structural and functional damage might be too advanced for effective modification or protection. Identification at the earliest stages of the disease course in the absence of Parkinsonism is crucial if we are to intervene when it matters most. Prognostic and therapeutic inferences can only be successful if we are able to accurately predict who is at risk for developing PD and if we can differentiate amongst the considerable clinicopathologic diversity. Biomarkers can greatly improve our identification and differentiation abilities if we are able to disentangle cause and effect. Frontiers Media S.A. 2020-07-08 /pmc/articles/PMC7360677/ /pubmed/32733372 http://dx.doi.org/10.3389/fneur.2020.00686 Text en Copyright © 2020 Poortvliet, O'Maley, Silburn and Mellick. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Poortvliet, Peter C.
O'Maley, Karen
Silburn, Peter A.
Mellick, George D.
Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease
title Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease
title_full Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease
title_fullStr Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease
title_full_unstemmed Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease
title_short Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease
title_sort perspective: current pitfalls in the search for future treatments and prevention of parkinson's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360677/
https://www.ncbi.nlm.nih.gov/pubmed/32733372
http://dx.doi.org/10.3389/fneur.2020.00686
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