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Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner

The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition receptors that engage DNA and require the adaptor...

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Detalles Bibliográficos
Autores principales:	Abraham, Jinu, Botto, Sara, Mizuno, Nobuyo, Pryke, Kara, Gall, Bryan, Boehm, Dylan, Sali, Tina M., Jin, Haihong, Nilsen, Aaron, Gough, Michael, Baird, Jason, Chakhtoura, Marita, Subra, Caroline, Trautmann, Lydie, Haddad, Elias K., DeFilippis, Victor R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360819/ https://www.ncbi.nlm.nih.gov/pubmed/32733475 http://dx.doi.org/10.3389/fimmu.2020.01430

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