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Future Perspective of Diabetic Animal Models
OBJECTIVE: The need of today’s research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. Enormous success of animal models had already been acclaimed for identifying key genetic and environmental factors like Idd loci and eff...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360914/ https://www.ncbi.nlm.nih.gov/pubmed/31241444 http://dx.doi.org/10.2174/1871530319666190626143832 |
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author | Pandey, Shashank Dvorakova, Magdalena C. |
author_facet | Pandey, Shashank Dvorakova, Magdalena C. |
author_sort | Pandey, Shashank |
collection | PubMed |
description | OBJECTIVE: The need of today’s research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. Enormous success of animal models had already been acclaimed for identifying key genetic and environmental factors like Idd loci and effects of microorganisms including the gut microbiota. Furthermore, animal models had also helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of a quite success, we have acknowledged that many of the discovered immunotherapies are working on animals and did not have a significant impact on human. Number of animal models were developed in the past to accelerate drug discovery pipeline. However, due to poor initial screening and assessment on inequivalent animal models, the percentage of drug candidates who succeeded during clinical trials was very low. Therefore, it is essential to bridge this gap between pre-clinical research and clinical trial by validating the existing animal models for consistency. RESULTS AND CONCLUSION: In this review, we have discussed and evaluated the significance of animal models on behalf of published data on PUBMED. Amongst the most popular diabetic animal models, we have selected six animal models (e.g. BioBreeding rat, “LEW IDDM rat”, “Nonobese Diabetic (NOD) mouse”, “STZ RAT”, “LEPR Mouse” and “Zucker Diabetic Fatty (ZDF) rat” and ranked them as per their published literature on PUBMED. Moreover, the vision and brief imagination for developing an advanced and robust diabetic model of 21(st) century was discussed with the theme of one mice-one human concept including organs-on-chips. |
format | Online Article Text |
id | pubmed-7360914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-73609142020-07-30 Future Perspective of Diabetic Animal Models Pandey, Shashank Dvorakova, Magdalena C. Endocr Metab Immune Disord Drug Targets Article OBJECTIVE: The need of today’s research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. Enormous success of animal models had already been acclaimed for identifying key genetic and environmental factors like Idd loci and effects of microorganisms including the gut microbiota. Furthermore, animal models had also helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of a quite success, we have acknowledged that many of the discovered immunotherapies are working on animals and did not have a significant impact on human. Number of animal models were developed in the past to accelerate drug discovery pipeline. However, due to poor initial screening and assessment on inequivalent animal models, the percentage of drug candidates who succeeded during clinical trials was very low. Therefore, it is essential to bridge this gap between pre-clinical research and clinical trial by validating the existing animal models for consistency. RESULTS AND CONCLUSION: In this review, we have discussed and evaluated the significance of animal models on behalf of published data on PUBMED. Amongst the most popular diabetic animal models, we have selected six animal models (e.g. BioBreeding rat, “LEW IDDM rat”, “Nonobese Diabetic (NOD) mouse”, “STZ RAT”, “LEPR Mouse” and “Zucker Diabetic Fatty (ZDF) rat” and ranked them as per their published literature on PUBMED. Moreover, the vision and brief imagination for developing an advanced and robust diabetic model of 21(st) century was discussed with the theme of one mice-one human concept including organs-on-chips. Bentham Science Publishers 2020-02 2020-02 /pmc/articles/PMC7360914/ /pubmed/31241444 http://dx.doi.org/10.2174/1871530319666190626143832 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Pandey, Shashank Dvorakova, Magdalena C. Future Perspective of Diabetic Animal Models |
title | Future Perspective of Diabetic Animal Models |
title_full | Future Perspective of Diabetic Animal Models |
title_fullStr | Future Perspective of Diabetic Animal Models |
title_full_unstemmed | Future Perspective of Diabetic Animal Models |
title_short | Future Perspective of Diabetic Animal Models |
title_sort | future perspective of diabetic animal models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360914/ https://www.ncbi.nlm.nih.gov/pubmed/31241444 http://dx.doi.org/10.2174/1871530319666190626143832 |
work_keys_str_mv | AT pandeyshashank futureperspectiveofdiabeticanimalmodels AT dvorakovamagdalenac futureperspectiveofdiabeticanimalmodels |