High percentage of smudge cells in a patient with COVID19: Rediscovering their utility

We present a patient with SARS‐CoV‐2 infection, with an unexpected presence of lymphocytosis. Examination of blood film revealed mature small lymphocytes associated with high percentage of smudge cells (63%). A peripheral flow cyometry evidenced a CD5 negative CLL. A high percentage of smudge cells...

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Detalles Bibliográficos
Autores principales: Jerez, Joaquín, Ernst, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Covid‐19
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361876/
https://www.ncbi.nlm.nih.gov/pubmed/32838400
http://dx.doi.org/10.1002/jha2.52
Descripción
Sumario:We present a patient with SARS‐CoV‐2 infection, with an unexpected presence of lymphocytosis. Examination of blood film revealed mature small lymphocytes associated with high percentage of smudge cells (63%). A peripheral flow cyometry evidenced a CD5 negative CLL. A high percentage of smudge cells is associated with CLL diagnosis and has an important prognostic value: better survival and prolonged time to first treatment. It is a useful index in developing countries with low access to molecular testing.

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