Cargando…
Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications
Hydrogenated styrenic block copolymers (HSBCs) have been used in medical tubing for many years due to their high clarity, flexibility, kink resistance, and toughness. However, when it comes to blood storage applications, HSBC compounds’ market has been limited because of their high hydrophobicity, w...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361970/ https://www.ncbi.nlm.nih.gov/pubmed/32549392 http://dx.doi.org/10.3390/polym12061351 |
_version_ | 1783559422708023296 |
---|---|
author | Tsai, Bin-Hong Chuang, Yung-Han Cheng, Chi-Hui Lin, Jui-Che |
author_facet | Tsai, Bin-Hong Chuang, Yung-Han Cheng, Chi-Hui Lin, Jui-Che |
author_sort | Tsai, Bin-Hong |
collection | PubMed |
description | Hydrogenated styrenic block copolymers (HSBCs) have been used in medical tubing for many years due to their high clarity, flexibility, kink resistance, and toughness. However, when it comes to blood storage applications, HSBC compounds’ market has been limited because of their high hydrophobicity, which may trigger platelet adhesion when contacting with blood. HSBC needs to be physically or chemically modified in advance to make it blood compatible; however, HSBC has strong UV/ozone resistance, thermooxidative stability, and excellent processing capability, which increases the difficulty of the chemical modification process as unsaturated dienes has been converted to saturated stable midblocks. Moreover, medical HSBC-containing compounds primarily make up with the non-polar, hydrophobic nature and benign characteristics of other common ingredients (U.S. Pharmacopeia (USP) grades of mineral oil and polypropylene), which complicates the realization of using HSBC-containing compounds in blood-contacting applications, and this explains why few studies had disclosed chemical modification for biocompatibility improvement on HSBC-containing compounds. Sulfonation has been reported as an effective way to improve the material’s blood/platelet compatibility. In this study, hydrogenated tert-butyl styrene (tBS)-styrene-isoprene block copolymers were synthesized and its blends with polypropylene and USP grades of mineral oil were selectively sulfonated by reaction with acetyl sulfate. By controlling the ratio of the hydrogenated tBS-styrene-isoprene block copolymer in the blend, sulfonated films were optimized to demonstrate sufficient physical integrity in water as well as thermal stability, hydrophilicity, and platelet compatibility. |
format | Online Article Text |
id | pubmed-7361970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73619702020-07-21 Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications Tsai, Bin-Hong Chuang, Yung-Han Cheng, Chi-Hui Lin, Jui-Che Polymers (Basel) Article Hydrogenated styrenic block copolymers (HSBCs) have been used in medical tubing for many years due to their high clarity, flexibility, kink resistance, and toughness. However, when it comes to blood storage applications, HSBC compounds’ market has been limited because of their high hydrophobicity, which may trigger platelet adhesion when contacting with blood. HSBC needs to be physically or chemically modified in advance to make it blood compatible; however, HSBC has strong UV/ozone resistance, thermooxidative stability, and excellent processing capability, which increases the difficulty of the chemical modification process as unsaturated dienes has been converted to saturated stable midblocks. Moreover, medical HSBC-containing compounds primarily make up with the non-polar, hydrophobic nature and benign characteristics of other common ingredients (U.S. Pharmacopeia (USP) grades of mineral oil and polypropylene), which complicates the realization of using HSBC-containing compounds in blood-contacting applications, and this explains why few studies had disclosed chemical modification for biocompatibility improvement on HSBC-containing compounds. Sulfonation has been reported as an effective way to improve the material’s blood/platelet compatibility. In this study, hydrogenated tert-butyl styrene (tBS)-styrene-isoprene block copolymers were synthesized and its blends with polypropylene and USP grades of mineral oil were selectively sulfonated by reaction with acetyl sulfate. By controlling the ratio of the hydrogenated tBS-styrene-isoprene block copolymer in the blend, sulfonated films were optimized to demonstrate sufficient physical integrity in water as well as thermal stability, hydrophilicity, and platelet compatibility. MDPI 2020-06-15 /pmc/articles/PMC7361970/ /pubmed/32549392 http://dx.doi.org/10.3390/polym12061351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tsai, Bin-Hong Chuang, Yung-Han Cheng, Chi-Hui Lin, Jui-Che Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications |
title | Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications |
title_full | Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications |
title_fullStr | Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications |
title_full_unstemmed | Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications |
title_short | Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications |
title_sort | sulfonation and characterization of tert-butyl styrene/styrene/isoprene copolymer and polypropylene blends for blood compatibility applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361970/ https://www.ncbi.nlm.nih.gov/pubmed/32549392 http://dx.doi.org/10.3390/polym12061351 |
work_keys_str_mv | AT tsaibinhong sulfonationandcharacterizationoftertbutylstyrenestyreneisoprenecopolymerandpolypropyleneblendsforbloodcompatibilityapplications AT chuangyunghan sulfonationandcharacterizationoftertbutylstyrenestyreneisoprenecopolymerandpolypropyleneblendsforbloodcompatibilityapplications AT chengchihui sulfonationandcharacterizationoftertbutylstyrenestyreneisoprenecopolymerandpolypropyleneblendsforbloodcompatibilityapplications AT linjuiche sulfonationandcharacterizationoftertbutylstyrenestyreneisoprenecopolymerandpolypropyleneblendsforbloodcompatibilityapplications |