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Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine

Herein, we present for the first time a novel potentiometric sensor based on the stimulus-responsive molecularly imprinted polymer (MIP) as a selective receptor for neutral dopamine determination. This smart receptor can change its capabilities to recognize according to external environmental stimul...

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Autores principales: H. Kamel, Ayman, Amr, Abd El-Galil E., Ashmawy, Nashwa H., Galal, Hoda R., Al-Omar, Mohamed A., Sayed, Ahmed Y.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362186/
https://www.ncbi.nlm.nih.gov/pubmed/32585949
http://dx.doi.org/10.3390/polym12061406
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author H. Kamel, Ayman
Amr, Abd El-Galil E.
Ashmawy, Nashwa H.
Galal, Hoda R.
Al-Omar, Mohamed A.
Sayed, Ahmed Y.A.
author_facet H. Kamel, Ayman
Amr, Abd El-Galil E.
Ashmawy, Nashwa H.
Galal, Hoda R.
Al-Omar, Mohamed A.
Sayed, Ahmed Y.A.
author_sort H. Kamel, Ayman
collection PubMed
description Herein, we present for the first time a novel potentiometric sensor based on the stimulus-responsive molecularly imprinted polymer (MIP) as a selective receptor for neutral dopamine determination. This smart receptor can change its capabilities to recognize according to external environmental stimuli. Therefore, MIP-binding sites can be regenerated in the polymeric membrane by stimulating with stimulus after each measurement. Based on this effect, reversible detection of the analyte via potentiometric transduction can be achieved. MIPs based on 4-vinylphenylboronic acid as the functional monomer were prepared as the selective receptor. This monomer can successfully bind to dopamine via covalent binding and forming a five- or six-membered cyclic ester in a weakly alkaline aqueous solution. In acidic medium, the produced ester dissociates and regenerates new binding sites in the polymeric membrane. The proposed smart sensor exhibited fast response and good sensitivity towards dopamine with a limit of detection 0.15 µM over the linear range 0.2–10 µM. The selectivity pattern of the proposed ISEs was also evaluated and revealed an enhanced selectivity towards dopamine over several phenolic compounds. Constant-current chronopotentiometry is used for evaluating the short-term potential stability of the proposed ISEs. The obtained results confirm that the stimulus-responsive MIPs provide an attractive way towards reversible MIP-based electrochemical sensors designation.
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spelling pubmed-73621862020-07-21 Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine H. Kamel, Ayman Amr, Abd El-Galil E. Ashmawy, Nashwa H. Galal, Hoda R. Al-Omar, Mohamed A. Sayed, Ahmed Y.A. Polymers (Basel) Article Herein, we present for the first time a novel potentiometric sensor based on the stimulus-responsive molecularly imprinted polymer (MIP) as a selective receptor for neutral dopamine determination. This smart receptor can change its capabilities to recognize according to external environmental stimuli. Therefore, MIP-binding sites can be regenerated in the polymeric membrane by stimulating with stimulus after each measurement. Based on this effect, reversible detection of the analyte via potentiometric transduction can be achieved. MIPs based on 4-vinylphenylboronic acid as the functional monomer were prepared as the selective receptor. This monomer can successfully bind to dopamine via covalent binding and forming a five- or six-membered cyclic ester in a weakly alkaline aqueous solution. In acidic medium, the produced ester dissociates and regenerates new binding sites in the polymeric membrane. The proposed smart sensor exhibited fast response and good sensitivity towards dopamine with a limit of detection 0.15 µM over the linear range 0.2–10 µM. The selectivity pattern of the proposed ISEs was also evaluated and revealed an enhanced selectivity towards dopamine over several phenolic compounds. Constant-current chronopotentiometry is used for evaluating the short-term potential stability of the proposed ISEs. The obtained results confirm that the stimulus-responsive MIPs provide an attractive way towards reversible MIP-based electrochemical sensors designation. MDPI 2020-06-23 /pmc/articles/PMC7362186/ /pubmed/32585949 http://dx.doi.org/10.3390/polym12061406 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
H. Kamel, Ayman
Amr, Abd El-Galil E.
Ashmawy, Nashwa H.
Galal, Hoda R.
Al-Omar, Mohamed A.
Sayed, Ahmed Y.A.
Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine
title Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine
title_full Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine
title_fullStr Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine
title_full_unstemmed Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine
title_short Solid-Contact Potentiometric Sensors Based on Stimulus-Responsive Imprinted Polymers for Reversible Detection of Neutral Dopamine
title_sort solid-contact potentiometric sensors based on stimulus-responsive imprinted polymers for reversible detection of neutral dopamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362186/
https://www.ncbi.nlm.nih.gov/pubmed/32585949
http://dx.doi.org/10.3390/polym12061406
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