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Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glyc...

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Autores principales: Ribeiro, Jessica P. M., Mendonça, Patrícia V., Coelho, Jorge F. J., Matyjaszewski, Krzysztof, Serra, Arménio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362234/
https://www.ncbi.nlm.nih.gov/pubmed/32492977
http://dx.doi.org/10.3390/polym12061268
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author Ribeiro, Jessica P. M.
Mendonça, Patrícia V.
Coelho, Jorge F. J.
Matyjaszewski, Krzysztof
Serra, Arménio C.
author_facet Ribeiro, Jessica P. M.
Mendonça, Patrícia V.
Coelho, Jorge F. J.
Matyjaszewski, Krzysztof
Serra, Arménio C.
author_sort Ribeiro, Jessica P. M.
collection PubMed
description The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested.
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spelling pubmed-73622342020-07-21 Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges Ribeiro, Jessica P. M. Mendonça, Patrícia V. Coelho, Jorge F. J. Matyjaszewski, Krzysztof Serra, Arménio C. Polymers (Basel) Review The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested. MDPI 2020-06-01 /pmc/articles/PMC7362234/ /pubmed/32492977 http://dx.doi.org/10.3390/polym12061268 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ribeiro, Jessica P. M.
Mendonça, Patrícia V.
Coelho, Jorge F. J.
Matyjaszewski, Krzysztof
Serra, Arménio C.
Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
title Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
title_full Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
title_fullStr Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
title_full_unstemmed Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
title_short Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
title_sort glycopolymer brushes by reversible deactivation radical polymerization: preparation, applications, and future challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362234/
https://www.ncbi.nlm.nih.gov/pubmed/32492977
http://dx.doi.org/10.3390/polym12061268
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