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Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges
The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glyc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362234/ https://www.ncbi.nlm.nih.gov/pubmed/32492977 http://dx.doi.org/10.3390/polym12061268 |
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author | Ribeiro, Jessica P. M. Mendonça, Patrícia V. Coelho, Jorge F. J. Matyjaszewski, Krzysztof Serra, Arménio C. |
author_facet | Ribeiro, Jessica P. M. Mendonça, Patrícia V. Coelho, Jorge F. J. Matyjaszewski, Krzysztof Serra, Arménio C. |
author_sort | Ribeiro, Jessica P. M. |
collection | PubMed |
description | The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested. |
format | Online Article Text |
id | pubmed-7362234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73622342020-07-21 Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges Ribeiro, Jessica P. M. Mendonça, Patrícia V. Coelho, Jorge F. J. Matyjaszewski, Krzysztof Serra, Arménio C. Polymers (Basel) Review The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested. MDPI 2020-06-01 /pmc/articles/PMC7362234/ /pubmed/32492977 http://dx.doi.org/10.3390/polym12061268 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ribeiro, Jessica P. M. Mendonça, Patrícia V. Coelho, Jorge F. J. Matyjaszewski, Krzysztof Serra, Arménio C. Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges |
title | Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges |
title_full | Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges |
title_fullStr | Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges |
title_full_unstemmed | Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges |
title_short | Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges |
title_sort | glycopolymer brushes by reversible deactivation radical polymerization: preparation, applications, and future challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362234/ https://www.ncbi.nlm.nih.gov/pubmed/32492977 http://dx.doi.org/10.3390/polym12061268 |
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