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Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?

The existence of polymyalgia rheumatica (PMR) with normal inflammatory indices at the time of diagnosis still represents a diagnostic conundrum. According to the literature, some patients with PMR following immune checkpoint inhibitory therapy had normal values of both erythrocyte sedimentation rate...

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Detalles Bibliográficos
Autores principales: Manzo, Ciro, Milchert, Marcin, Natale, Maria, Brzosko, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362269/
https://www.ncbi.nlm.nih.gov/pubmed/32684653
http://dx.doi.org/10.5114/reum.2020.96549
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author Manzo, Ciro
Milchert, Marcin
Natale, Maria
Brzosko, Marek
author_facet Manzo, Ciro
Milchert, Marcin
Natale, Maria
Brzosko, Marek
author_sort Manzo, Ciro
collection PubMed
description The existence of polymyalgia rheumatica (PMR) with normal inflammatory indices at the time of diagnosis still represents a diagnostic conundrum. According to the literature, some patients with PMR following immune checkpoint inhibitory therapy had normal values of both erythrocyte sedimentation rate and C-reactive protein concentrations at the time of diagnosis. In this short communication we investigated the possibility that in some patients with PMR the main pathogenic mechanism is constituted by inhibition of some checkpoints, such as programmed death receptor-1, programmed death ligand 1, and “cytotoxic” lymphocyte antigen 4. In these patients, the pathogenetic mechanisms underlying PMR can act much more upstream than commonly suggested. Also, we addressed the question of whether these patients should be considered as affected by PMR-like syndromes or by PMR subset.
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spelling pubmed-73622692020-07-17 Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward? Manzo, Ciro Milchert, Marcin Natale, Maria Brzosko, Marek Reumatologia Short Communication The existence of polymyalgia rheumatica (PMR) with normal inflammatory indices at the time of diagnosis still represents a diagnostic conundrum. According to the literature, some patients with PMR following immune checkpoint inhibitory therapy had normal values of both erythrocyte sedimentation rate and C-reactive protein concentrations at the time of diagnosis. In this short communication we investigated the possibility that in some patients with PMR the main pathogenic mechanism is constituted by inhibition of some checkpoints, such as programmed death receptor-1, programmed death ligand 1, and “cytotoxic” lymphocyte antigen 4. In these patients, the pathogenetic mechanisms underlying PMR can act much more upstream than commonly suggested. Also, we addressed the question of whether these patients should be considered as affected by PMR-like syndromes or by PMR subset. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2020-06-29 2020 /pmc/articles/PMC7362269/ /pubmed/32684653 http://dx.doi.org/10.5114/reum.2020.96549 Text en Copyright: © 2020 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Short Communication
Manzo, Ciro
Milchert, Marcin
Natale, Maria
Brzosko, Marek
Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_full Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_fullStr Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_full_unstemmed Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_short Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_sort polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362269/
https://www.ncbi.nlm.nih.gov/pubmed/32684653
http://dx.doi.org/10.5114/reum.2020.96549
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