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Ribosomes: An Exciting Avenue in Stem Cell Research
Stem cell research has focused on genomic studies. However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. Ribosomes play a crucial role in epigenetic regulation, and thus, we focused on the role of ribosomes in stem cells. Majority of l...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362291/ https://www.ncbi.nlm.nih.gov/pubmed/32695182 http://dx.doi.org/10.1155/2020/8863539 |
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author | Han, Zhenzhen Zhang, Qi Zhu, Yanbo Chen, Jingcheng Li, Wei |
author_facet | Han, Zhenzhen Zhang, Qi Zhu, Yanbo Chen, Jingcheng Li, Wei |
author_sort | Han, Zhenzhen |
collection | PubMed |
description | Stem cell research has focused on genomic studies. However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. Ribosomes play a crucial role in epigenetic regulation, and thus, we focused on the role of ribosomes in stem cells. Majority of living organisms possess ribosomes that are involved in the translation of mRNA into proteins and promote cellular proliferation and differentiation. Ribosomes are stable molecular machines that play a role with changes in the levels of RNA during translation. Recent research suggests that specific ribosomes actively regulate gene expression in multiple cell types, such as stem cells. Stem cells have the potential for self-renewal and differentiation into multiple lineages and, thus, require high efficiency of translation. Ribosomes induce cellular transdifferentiation and reprogramming, and disrupted ribosome synthesis affects translation efficiency, thereby hindering stem cell function leading to cell death and differentiation. Stem cell function is regulated by ribosome-mediated control of stem cell-specific gene expression. In this review, we have presented a detailed discourse on the characteristics of ribosomes in stem cells. Understanding ribosome biology in stem cells will provide insights into the regulation of stem cell function and cellular reprogramming. |
format | Online Article Text |
id | pubmed-7362291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73622912020-07-20 Ribosomes: An Exciting Avenue in Stem Cell Research Han, Zhenzhen Zhang, Qi Zhu, Yanbo Chen, Jingcheng Li, Wei Stem Cells Int Review Article Stem cell research has focused on genomic studies. However, recent evidence has indicated the involvement of epigenetic regulation in determining the fate of stem cells. Ribosomes play a crucial role in epigenetic regulation, and thus, we focused on the role of ribosomes in stem cells. Majority of living organisms possess ribosomes that are involved in the translation of mRNA into proteins and promote cellular proliferation and differentiation. Ribosomes are stable molecular machines that play a role with changes in the levels of RNA during translation. Recent research suggests that specific ribosomes actively regulate gene expression in multiple cell types, such as stem cells. Stem cells have the potential for self-renewal and differentiation into multiple lineages and, thus, require high efficiency of translation. Ribosomes induce cellular transdifferentiation and reprogramming, and disrupted ribosome synthesis affects translation efficiency, thereby hindering stem cell function leading to cell death and differentiation. Stem cell function is regulated by ribosome-mediated control of stem cell-specific gene expression. In this review, we have presented a detailed discourse on the characteristics of ribosomes in stem cells. Understanding ribosome biology in stem cells will provide insights into the regulation of stem cell function and cellular reprogramming. Hindawi 2020-07-06 /pmc/articles/PMC7362291/ /pubmed/32695182 http://dx.doi.org/10.1155/2020/8863539 Text en Copyright © 2020 Zhenzhen Han et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Han, Zhenzhen Zhang, Qi Zhu, Yanbo Chen, Jingcheng Li, Wei Ribosomes: An Exciting Avenue in Stem Cell Research |
title | Ribosomes: An Exciting Avenue in Stem Cell Research |
title_full | Ribosomes: An Exciting Avenue in Stem Cell Research |
title_fullStr | Ribosomes: An Exciting Avenue in Stem Cell Research |
title_full_unstemmed | Ribosomes: An Exciting Avenue in Stem Cell Research |
title_short | Ribosomes: An Exciting Avenue in Stem Cell Research |
title_sort | ribosomes: an exciting avenue in stem cell research |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362291/ https://www.ncbi.nlm.nih.gov/pubmed/32695182 http://dx.doi.org/10.1155/2020/8863539 |
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