Parkin and PINK1 mitigate STING-induced inflammation

Although serum from Parkinson’s disease (PD) patients displays elevated levels of numerous pro-inflammatory cytokines including IL-6, TNFα, IL-1β, and IFNβ1, whether inflammation contributes to or is a consequence of neuronal loss remains unknown(1). Mutations in Parkin, an E3 ubiquitin ligase, and...

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Detalles Bibliográficos
Autores principales: Sliter, Danielle A., Martinez, Jennifer, Hao, Ling, Chen, Xi, Sun, Nuo, Fischer, Tara D., Burman, Jonathon L., Li, Yan, Zhang, Zhe, Narendra, Derek P., Cai, Huaibin, Borsche, Max, Klein, Christine, Youle, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362342/
https://www.ncbi.nlm.nih.gov/pubmed/30135585
http://dx.doi.org/10.1038/s41586-018-0448-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362342/
https://www.ncbi.nlm.nih.gov/pubmed/30135585
http://dx.doi.org/10.1038/s41586-018-0448-9

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