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Parkin and PINK1 mitigate STING-induced inflammation
Although serum from Parkinson’s disease (PD) patients displays elevated levels of numerous pro-inflammatory cytokines including IL-6, TNFα, IL-1β, and IFNβ1, whether inflammation contributes to or is a consequence of neuronal loss remains unknown(1). Mutations in Parkin, an E3 ubiquitin ligase, and...
Autores principales: | Sliter, Danielle A., Martinez, Jennifer, Hao, Ling, Chen, Xi, Sun, Nuo, Fischer, Tara D., Burman, Jonathon L., Li, Yan, Zhang, Zhe, Narendra, Derek P., Cai, Huaibin, Borsche, Max, Klein, Christine, Youle, Richard J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362342/ https://www.ncbi.nlm.nih.gov/pubmed/30135585 http://dx.doi.org/10.1038/s41586-018-0448-9 |
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