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Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives

In this study, 5-amino-nicotinic acid derivatives (1–13) have been designed and synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase enzymes. The synthesized compounds (1–13) exhibited promising α-amylase and α-glucosidase activities. IC(50) values for α-amylase act...

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Autores principales: Nawaz, Muhammad, Taha, Muhammad, Qureshi, Faiza, Ullah, Nisar, Selvaraj, Manikandan, Shahzad, Sumaira, Chigurupati, Sridevi, Waheed, Abdul, Almutairi, Fadiah Ammar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362424/
https://www.ncbi.nlm.nih.gov/pubmed/32685927
http://dx.doi.org/10.1186/s13065-020-00695-1
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author Nawaz, Muhammad
Taha, Muhammad
Qureshi, Faiza
Ullah, Nisar
Selvaraj, Manikandan
Shahzad, Sumaira
Chigurupati, Sridevi
Waheed, Abdul
Almutairi, Fadiah Ammar
author_facet Nawaz, Muhammad
Taha, Muhammad
Qureshi, Faiza
Ullah, Nisar
Selvaraj, Manikandan
Shahzad, Sumaira
Chigurupati, Sridevi
Waheed, Abdul
Almutairi, Fadiah Ammar
author_sort Nawaz, Muhammad
collection PubMed
description In this study, 5-amino-nicotinic acid derivatives (1–13) have been designed and synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase enzymes. The synthesized compounds (1–13) exhibited promising α-amylase and α-glucosidase activities. IC(50) values for α-amylase activity ranged between 12.17 ± 0.14 to 37.33 ± 0.02 µg/mL ± SEM while for α-glucosidase activity the IC(50) values were ranged between 12.01 ± 0.09 to 38.01 ± 0.12 µg/mL ± SEM. In particular, compounds 2 and 4–8 demonstrated significant inhibitory activities against α-amylase and α-glucosidase and the inhibitory potential of these compounds was comparable to the standard acarbose (10.98 ± 0.03 and 10.79 ± 0.17 µg/mL ± SEM, respectively). In addition, the impact of substituent on the inhibitory potential of these compounds was assessed to establish structure activity relationships. Studies in molecular simulations were conducted to better comprehend the binding properties of the compounds. All the synthesized compounds were extensively characterized with modern spectroscopic methods including (1)H-NMR, (13)C–NMR, FTIR, HR-MS and elemental analysis. [Image: see text]
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spelling pubmed-73624242020-07-17 Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives Nawaz, Muhammad Taha, Muhammad Qureshi, Faiza Ullah, Nisar Selvaraj, Manikandan Shahzad, Sumaira Chigurupati, Sridevi Waheed, Abdul Almutairi, Fadiah Ammar BMC Chem Research Article In this study, 5-amino-nicotinic acid derivatives (1–13) have been designed and synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase enzymes. The synthesized compounds (1–13) exhibited promising α-amylase and α-glucosidase activities. IC(50) values for α-amylase activity ranged between 12.17 ± 0.14 to 37.33 ± 0.02 µg/mL ± SEM while for α-glucosidase activity the IC(50) values were ranged between 12.01 ± 0.09 to 38.01 ± 0.12 µg/mL ± SEM. In particular, compounds 2 and 4–8 demonstrated significant inhibitory activities against α-amylase and α-glucosidase and the inhibitory potential of these compounds was comparable to the standard acarbose (10.98 ± 0.03 and 10.79 ± 0.17 µg/mL ± SEM, respectively). In addition, the impact of substituent on the inhibitory potential of these compounds was assessed to establish structure activity relationships. Studies in molecular simulations were conducted to better comprehend the binding properties of the compounds. All the synthesized compounds were extensively characterized with modern spectroscopic methods including (1)H-NMR, (13)C–NMR, FTIR, HR-MS and elemental analysis. [Image: see text] Springer International Publishing 2020-07-14 /pmc/articles/PMC7362424/ /pubmed/32685927 http://dx.doi.org/10.1186/s13065-020-00695-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Nawaz, Muhammad
Taha, Muhammad
Qureshi, Faiza
Ullah, Nisar
Selvaraj, Manikandan
Shahzad, Sumaira
Chigurupati, Sridevi
Waheed, Abdul
Almutairi, Fadiah Ammar
Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
title Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
title_full Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
title_fullStr Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
title_full_unstemmed Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
title_short Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
title_sort structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362424/
https://www.ncbi.nlm.nih.gov/pubmed/32685927
http://dx.doi.org/10.1186/s13065-020-00695-1
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