Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

BACKGROUND: Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with intact expression of MLH1 and MSH2. CASE PRESENTATION: We review the frequency of...

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Detalles Bibliográficos
Autores principales: Moreno, Esther, Rosa-Rosa, Juan M., Caniego-Casas, Tamara, Ruz-Caracuel, Ignacio, Perna, Cristian, Guillén, Carmen, Palacios, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362514/
https://www.ncbi.nlm.nih.gov/pubmed/32664968
http://dx.doi.org/10.1186/s13000-020-01001-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362514/
https://www.ncbi.nlm.nih.gov/pubmed/32664968
http://dx.doi.org/10.1186/s13000-020-01001-2

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