Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological a...

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Autores principales: Nebigil, Canan G., Moog, Christiane, Vagner, Stéphan, Benkirane-Jessel, Nadia, Smith, Duncan R., Désaubry, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362831/
https://www.ncbi.nlm.nih.gov/pubmed/32693294
http://dx.doi.org/10.1016/j.ejmech.2020.112653
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author Nebigil, Canan G.
Moog, Christiane
Vagner, Stéphan
Benkirane-Jessel, Nadia
Smith, Duncan R.
Désaubry, Laurent
author_facet Nebigil, Canan G.
Moog, Christiane
Vagner, Stéphan
Benkirane-Jessel, Nadia
Smith, Duncan R.
Désaubry, Laurent
author_sort Nebigil, Canan G.
collection PubMed
description Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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spelling pubmed-73628312020-09-11 Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses Nebigil, Canan G. Moog, Christiane Vagner, Stéphan Benkirane-Jessel, Nadia Smith, Duncan R. Désaubry, Laurent Eur J Med Chem Research Paper Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Elsevier Masson SAS. 2020-10-01 2020-07-15 /pmc/articles/PMC7362831/ /pubmed/32693294 http://dx.doi.org/10.1016/j.ejmech.2020.112653 Text en © 2020 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Nebigil, Canan G.
Moog, Christiane
Vagner, Stéphan
Benkirane-Jessel, Nadia
Smith, Duncan R.
Désaubry, Laurent
Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
title Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
title_full Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
title_fullStr Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
title_full_unstemmed Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
title_short Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses
title_sort flavaglines as natural products targeting eif4a and prohibitins: from traditional chinese medicine to antiviral activity against coronaviruses
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362831/
https://www.ncbi.nlm.nih.gov/pubmed/32693294
http://dx.doi.org/10.1016/j.ejmech.2020.112653
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