Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction

Low-dose methotrexate (MTX) is the backbone of treatment for extensive psoriasis vulgaris not responding to topical therapy. Since its induction for the treatment of psoriasis in the 1970, its short- and long-term side effect profile has been extensively studied. Hair loss with MTX has been reported...

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Autores principales: Sinha, Preema, Bhatt, Siddharth, Radhakrishnan, Subramaniyan, Neema, Shekhar, Sinha, Anwita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362964/
https://www.ncbi.nlm.nih.gov/pubmed/32684684
http://dx.doi.org/10.4103/ijt.ijt_49_20
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author Sinha, Preema
Bhatt, Siddharth
Radhakrishnan, Subramaniyan
Neema, Shekhar
Sinha, Anwita
author_facet Sinha, Preema
Bhatt, Siddharth
Radhakrishnan, Subramaniyan
Neema, Shekhar
Sinha, Anwita
author_sort Sinha, Preema
collection PubMed
description Low-dose methotrexate (MTX) is the backbone of treatment for extensive psoriasis vulgaris not responding to topical therapy. Since its induction for the treatment of psoriasis in the 1970, its short- and long-term side effect profile has been extensively studied. Hair loss with MTX has been reported mostly with high-dose MTX used in chemotherapy. Here, we report a case of guttate psoriasis who presented with acute-onset anagen effluvium following the administration of only two doses of MTX 7.5 mg per week.
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spelling pubmed-73629642020-07-17 Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction Sinha, Preema Bhatt, Siddharth Radhakrishnan, Subramaniyan Neema, Shekhar Sinha, Anwita Int J Trichology Case Report Low-dose methotrexate (MTX) is the backbone of treatment for extensive psoriasis vulgaris not responding to topical therapy. Since its induction for the treatment of psoriasis in the 1970, its short- and long-term side effect profile has been extensively studied. Hair loss with MTX has been reported mostly with high-dose MTX used in chemotherapy. Here, we report a case of guttate psoriasis who presented with acute-onset anagen effluvium following the administration of only two doses of MTX 7.5 mg per week. Wolters Kluwer - Medknow 2020 2020-05-05 /pmc/articles/PMC7362964/ /pubmed/32684684 http://dx.doi.org/10.4103/ijt.ijt_49_20 Text en Copyright: © 2020 International Journal of Trichology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sinha, Preema
Bhatt, Siddharth
Radhakrishnan, Subramaniyan
Neema, Shekhar
Sinha, Anwita
Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction
title Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction
title_full Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction
title_fullStr Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction
title_full_unstemmed Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction
title_short Anagen Effluvium after Methotrexate: An Idiosyncratic Reaction
title_sort anagen effluvium after methotrexate: an idiosyncratic reaction
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362964/
https://www.ncbi.nlm.nih.gov/pubmed/32684684
http://dx.doi.org/10.4103/ijt.ijt_49_20
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