Cargando…

Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study

BACKGROUND: The hair whorl denotes the spiral disposition of hairs around an axis, which is determined by the follicle growing direction. Atypical variants of scalp hair patterns, identified by abnormally placed or multiple whorls, have been associated with early brain developmental disorders and se...

Descripción completa

Detalles Bibliográficos
Autores principales: Sechi, Andrea, Neri, Iria, Patrizi, Annalisa, Starace, Michela, Savoia, Francesco, Leuzzi, Miriam, Caposiena Caro, Raffaele Dante, Piraccini, Bianca Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362971/
https://www.ncbi.nlm.nih.gov/pubmed/32684676
http://dx.doi.org/10.4103/ijt.ijt_25_20
_version_ 1783559589261737984
author Sechi, Andrea
Neri, Iria
Patrizi, Annalisa
Starace, Michela
Savoia, Francesco
Leuzzi, Miriam
Caposiena Caro, Raffaele Dante
Piraccini, Bianca Maria
author_facet Sechi, Andrea
Neri, Iria
Patrizi, Annalisa
Starace, Michela
Savoia, Francesco
Leuzzi, Miriam
Caposiena Caro, Raffaele Dante
Piraccini, Bianca Maria
author_sort Sechi, Andrea
collection PubMed
description BACKGROUND: The hair whorl denotes the spiral disposition of hairs around an axis, which is determined by the follicle growing direction. Atypical variants of scalp hair patterns, identified by abnormally placed or multiple whorls, have been associated with early brain developmental disorders and several dysmorphic syndromes. MATERIALS AND METHODS: A 6-month case–control, prospective monocentric study included an overall number of 557 children. A logistic regression analysis was performed to evaluate the relationship between localization, the number of scalp hair whorls, and their association with neurofibromatosis type 1 (NF1). RESULTS: NF1 positively correlates with a frontal localization, whereas a negative association was found with a parietal whorl pattern (P < 0.001). CONCLUSION: Evaluation of scalp whorls gains importance in the neonatal settings and may contribute to suspect the early diagnosis of NF1, as the related National Institutes of Health diagnostic criteria cannot be usually observed at an early age.
format Online
Article
Text
id pubmed-7362971
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-73629712020-07-17 Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study Sechi, Andrea Neri, Iria Patrizi, Annalisa Starace, Michela Savoia, Francesco Leuzzi, Miriam Caposiena Caro, Raffaele Dante Piraccini, Bianca Maria Int J Trichology Original Article BACKGROUND: The hair whorl denotes the spiral disposition of hairs around an axis, which is determined by the follicle growing direction. Atypical variants of scalp hair patterns, identified by abnormally placed or multiple whorls, have been associated with early brain developmental disorders and several dysmorphic syndromes. MATERIALS AND METHODS: A 6-month case–control, prospective monocentric study included an overall number of 557 children. A logistic regression analysis was performed to evaluate the relationship between localization, the number of scalp hair whorls, and their association with neurofibromatosis type 1 (NF1). RESULTS: NF1 positively correlates with a frontal localization, whereas a negative association was found with a parietal whorl pattern (P < 0.001). CONCLUSION: Evaluation of scalp whorls gains importance in the neonatal settings and may contribute to suspect the early diagnosis of NF1, as the related National Institutes of Health diagnostic criteria cannot be usually observed at an early age. Wolters Kluwer - Medknow 2020 2020-05-05 /pmc/articles/PMC7362971/ /pubmed/32684676 http://dx.doi.org/10.4103/ijt.ijt_25_20 Text en Copyright: © 2020 International Journal of Trichology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sechi, Andrea
Neri, Iria
Patrizi, Annalisa
Starace, Michela
Savoia, Francesco
Leuzzi, Miriam
Caposiena Caro, Raffaele Dante
Piraccini, Bianca Maria
Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study
title Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study
title_full Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study
title_fullStr Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study
title_full_unstemmed Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study
title_short Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study
title_sort scalp hair whorl patterns in patients affected by neurofibromatosis type 1: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362971/
https://www.ncbi.nlm.nih.gov/pubmed/32684676
http://dx.doi.org/10.4103/ijt.ijt_25_20
work_keys_str_mv AT sechiandrea scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT neriiria scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT patriziannalisa scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT staracemichela scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT savoiafrancesco scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT leuzzimiriam scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT caposienacaroraffaeledante scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy
AT piraccinibiancamaria scalphairwhorlpatternsinpatientsaffectedbyneurofibromatosistype1acasecontrolstudy