Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

The accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and other tauopathies. Molecular chaperones are known to maintain protein homeostasis. Here, we show that an ATP-dependent human chaperone system disassembles Tau fibrils in vitro. We found that this function i...

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Detalles Bibliográficos
Autores principales: Nachman, Eliana, Wentink, Anne S., Madiona, Karine, Bousset, Luc, Katsinelos, Taxiarchis, Allinson, Kieren, Kampinga, Harm, McEwan, William A., Jahn, Thomas R., Melki, Ronald, Mogk, Axel, Bukau, Bernd, Nussbaum-Krammer, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363153/
https://www.ncbi.nlm.nih.gov/pubmed/32467226
http://dx.doi.org/10.1074/jbc.RA120.013478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363153/
https://www.ncbi.nlm.nih.gov/pubmed/32467226
http://dx.doi.org/10.1074/jbc.RA120.013478

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