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Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples
Sleep is pivotal for memory consolidation. According to two-stage accounts, memory traces are gradually translocated from hippocampus to neocortex during non-rapid-eye-movement (NREM) sleep. Mechanistically, this information transfer is thought to rely on interactions between thalamocortical spindle...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363445/ https://www.ncbi.nlm.nih.gov/pubmed/32657268 http://dx.doi.org/10.7554/eLife.57011 |
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author | Ngo, Hong-Viet Fell, Juergen Staresina, Bernhard |
author_facet | Ngo, Hong-Viet Fell, Juergen Staresina, Bernhard |
author_sort | Ngo, Hong-Viet |
collection | PubMed |
description | Sleep is pivotal for memory consolidation. According to two-stage accounts, memory traces are gradually translocated from hippocampus to neocortex during non-rapid-eye-movement (NREM) sleep. Mechanistically, this information transfer is thought to rely on interactions between thalamocortical spindles and hippocampal ripples. To test this hypothesis, we analyzed intracranial and scalp Electroencephalography sleep recordings from pre-surgical epilepsy patients. We first observed a concurrent spindle power increase in hippocampus (HIPP) and neocortex (NC) time-locked to individual hippocampal ripple events. Coherence analysis confirmed elevated levels of hippocampal-neocortical spindle coupling around ripples, with directionality analyses indicating an influence from NC to HIPP. Importantly, these hippocampal-neocortical dynamics were particularly pronounced during long-duration compared to short-duration ripples. Together, our findings reveal a potential mechanism underlying active consolidation, comprising a neocortical-hippocampal-neocortical reactivation loop initiated by the neocortex. This hippocampal-cortical dialogue is mediated by sleep spindles and is enhanced during long-duration hippocampal ripples. |
format | Online Article Text |
id | pubmed-7363445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-73634452020-07-17 Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples Ngo, Hong-Viet Fell, Juergen Staresina, Bernhard eLife Neuroscience Sleep is pivotal for memory consolidation. According to two-stage accounts, memory traces are gradually translocated from hippocampus to neocortex during non-rapid-eye-movement (NREM) sleep. Mechanistically, this information transfer is thought to rely on interactions between thalamocortical spindles and hippocampal ripples. To test this hypothesis, we analyzed intracranial and scalp Electroencephalography sleep recordings from pre-surgical epilepsy patients. We first observed a concurrent spindle power increase in hippocampus (HIPP) and neocortex (NC) time-locked to individual hippocampal ripple events. Coherence analysis confirmed elevated levels of hippocampal-neocortical spindle coupling around ripples, with directionality analyses indicating an influence from NC to HIPP. Importantly, these hippocampal-neocortical dynamics were particularly pronounced during long-duration compared to short-duration ripples. Together, our findings reveal a potential mechanism underlying active consolidation, comprising a neocortical-hippocampal-neocortical reactivation loop initiated by the neocortex. This hippocampal-cortical dialogue is mediated by sleep spindles and is enhanced during long-duration hippocampal ripples. eLife Sciences Publications, Ltd 2020-07-13 /pmc/articles/PMC7363445/ /pubmed/32657268 http://dx.doi.org/10.7554/eLife.57011 Text en © 2020, Ngo et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Ngo, Hong-Viet Fell, Juergen Staresina, Bernhard Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
title | Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
title_full | Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
title_fullStr | Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
title_full_unstemmed | Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
title_short | Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
title_sort | sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363445/ https://www.ncbi.nlm.nih.gov/pubmed/32657268 http://dx.doi.org/10.7554/eLife.57011 |
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