Late-onset corneal haze after intrastromal corneal ring implantation in an eye with previous topography-guided PRK

PURPOSE: To report a case of late-onset corneal haze 3 months after intrastromal corneal ring segment (ICRS) implantation in an eye with previous transepithelial topography-guided photorefractive keratectomy (TG-PRK). OBSERVATIONS: A 40-year-old woman with stable keratoconus for 10 years underwent limited TG-PRK with mitomycin C in both eyes for mixed astigmatism. After four years, with atopic symptoms worsening and eye rubbing, the patient presented keratoconus progression in the left eye with increased irregular astigmatism. An ICRS was implanted with initial improvement in vision. Three months later severe subepithelial haze was observed along the ring groove. CONCLUSION AND IMPORTANCE: This is the first report of subepithelial haze after ICRS implantation. This report increases the evidence that permanent corneal wound healing changes occur after PRK and that late-onset haze may be triggered by corneal remodeling, as little inflammation or epithelial defect occurs after ICRS implantation. We do believe the detection of triggers, identification of risk factors of late-onset haze and appropriate preoperative counselling have an increasing importance due to the rising number of patients that have undergone PRK.