The bright and dark sides of protein conformational switches and the unifying forces of infections

It is now established that a protein can switch between multiple conformations to enable altered functions. Several pathogens including SARS COV2 utilize context-dependent conformational switches of particular proteins to invade host membrane to establish infections. In this perspective, we first di...

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Autores principales: Sannigrahi, Achinta, De, Nayan, Chattopadhyay, Krishnananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363679/
https://www.ncbi.nlm.nih.gov/pubmed/32669705
http://dx.doi.org/10.1038/s42003-020-1115-x
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author Sannigrahi, Achinta
De, Nayan
Chattopadhyay, Krishnananda
author_facet Sannigrahi, Achinta
De, Nayan
Chattopadhyay, Krishnananda
author_sort Sannigrahi, Achinta
collection PubMed
description It is now established that a protein can switch between multiple conformations to enable altered functions. Several pathogens including SARS COV2 utilize context-dependent conformational switches of particular proteins to invade host membrane to establish infections. In this perspective, we first discuss the understanding of the conformational switch of a protein towards the productive infections as a dark side of nature. Next, the unexplored binary combination of the sequences of SARS COV2 spike protein and the similarity with diverse pathogen derived proteins have been discussed to obtain novel molecular insights into the process of infection.
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spelling pubmed-73636792020-07-20 The bright and dark sides of protein conformational switches and the unifying forces of infections Sannigrahi, Achinta De, Nayan Chattopadhyay, Krishnananda Commun Biol Perspective It is now established that a protein can switch between multiple conformations to enable altered functions. Several pathogens including SARS COV2 utilize context-dependent conformational switches of particular proteins to invade host membrane to establish infections. In this perspective, we first discuss the understanding of the conformational switch of a protein towards the productive infections as a dark side of nature. Next, the unexplored binary combination of the sequences of SARS COV2 spike protein and the similarity with diverse pathogen derived proteins have been discussed to obtain novel molecular insights into the process of infection. Nature Publishing Group UK 2020-07-15 /pmc/articles/PMC7363679/ /pubmed/32669705 http://dx.doi.org/10.1038/s42003-020-1115-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Sannigrahi, Achinta
De, Nayan
Chattopadhyay, Krishnananda
The bright and dark sides of protein conformational switches and the unifying forces of infections
title The bright and dark sides of protein conformational switches and the unifying forces of infections
title_full The bright and dark sides of protein conformational switches and the unifying forces of infections
title_fullStr The bright and dark sides of protein conformational switches and the unifying forces of infections
title_full_unstemmed The bright and dark sides of protein conformational switches and the unifying forces of infections
title_short The bright and dark sides of protein conformational switches and the unifying forces of infections
title_sort bright and dark sides of protein conformational switches and the unifying forces of infections
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363679/
https://www.ncbi.nlm.nih.gov/pubmed/32669705
http://dx.doi.org/10.1038/s42003-020-1115-x
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