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RNAi suppressor: The hidden weapon of SARS-CoV
The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer India
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363689/ https://www.ncbi.nlm.nih.gov/pubmed/32713862 http://dx.doi.org/10.1007/s12038-020-00071-0 |
| _version_ | 1783559685557714944 |
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| author | Karjee, Sumona Mukherjee, Sunil Kumar |
| author_facet | Karjee, Sumona Mukherjee, Sunil Kumar |
| author_sort | Karjee, Sumona |
| collection | PubMed |
| description | The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question. |
| format | Online Article Text |
| id | pubmed-7363689 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Springer India |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-73636892020-07-16 RNAi suppressor: The hidden weapon of SARS-CoV Karjee, Sumona Mukherjee, Sunil Kumar J Biosci Review The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question. Springer India 2020-07-16 2020 /pmc/articles/PMC7363689/ /pubmed/32713862 http://dx.doi.org/10.1007/s12038-020-00071-0 Text en © Indian Academy of Sciences 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Review Karjee, Sumona Mukherjee, Sunil Kumar RNAi suppressor: The hidden weapon of SARS-CoV |
| title | RNAi suppressor: The hidden weapon of SARS-CoV |
| title_full | RNAi suppressor: The hidden weapon of SARS-CoV |
| title_fullStr | RNAi suppressor: The hidden weapon of SARS-CoV |
| title_full_unstemmed | RNAi suppressor: The hidden weapon of SARS-CoV |
| title_short | RNAi suppressor: The hidden weapon of SARS-CoV |
| title_sort | rnai suppressor: the hidden weapon of sars-cov |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363689/ https://www.ncbi.nlm.nih.gov/pubmed/32713862 http://dx.doi.org/10.1007/s12038-020-00071-0 |
| work_keys_str_mv | AT karjeesumona rnaisuppressorthehiddenweaponofsarscov AT mukherjeesunilkumar rnaisuppressorthehiddenweaponofsarscov |