Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relations...

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Autores principales: Liu, Han-jie, Hu, Hui-min, Li, Guan-zhang, Zhang, Ying, Wu, Fan, Liu, Xiu, Wang, Kuan-yu, Zhang, Chuan-bao, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363771/
https://www.ncbi.nlm.nih.gov/pubmed/32733879
http://dx.doi.org/10.3389/fcell.2020.00538
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author Liu, Han-jie
Hu, Hui-min
Li, Guan-zhang
Zhang, Ying
Wu, Fan
Liu, Xiu
Wang, Kuan-yu
Zhang, Chuan-bao
Jiang, Tao
author_facet Liu, Han-jie
Hu, Hui-min
Li, Guan-zhang
Zhang, Ying
Wu, Fan
Liu, Xiu
Wang, Kuan-yu
Zhang, Chuan-bao
Jiang, Tao
author_sort Liu, Han-jie
collection PubMed
description Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.
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spelling pubmed-73637712020-07-29 Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression Liu, Han-jie Hu, Hui-min Li, Guan-zhang Zhang, Ying Wu, Fan Liu, Xiu Wang, Kuan-yu Zhang, Chuan-bao Jiang, Tao Front Cell Dev Biol Cell and Developmental Biology Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression. Frontiers Media S.A. 2020-07-09 /pmc/articles/PMC7363771/ /pubmed/32733879 http://dx.doi.org/10.3389/fcell.2020.00538 Text en Copyright © 2020 Liu, Hu, Li, Zhang, Wu, Liu, Wang, Zhang and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Han-jie
Hu, Hui-min
Li, Guan-zhang
Zhang, Ying
Wu, Fan
Liu, Xiu
Wang, Kuan-yu
Zhang, Chuan-bao
Jiang, Tao
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_full Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_fullStr Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_full_unstemmed Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_short Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_sort ferroptosis-related gene signature predicts glioma cell death and glioma patient progression
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363771/
https://www.ncbi.nlm.nih.gov/pubmed/32733879
http://dx.doi.org/10.3389/fcell.2020.00538
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