Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway

Ca(2+) signaling in pulmonary arterial smooth muscle cells (PASMCs) plays an important role in pulmonary hypertension (PH). However, the underlying specific ion channel mechanisms remain largely unknown. Here, we report ryanodine receptor (RyR) channel activity and Ca(2+) release both are increased,...

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Detalles Bibliográficos
Autores principales: Mei, Lin, Zheng, Yun-Min, Song, Tengyao, Yadav, Vishal R., Joseph, Leroy C., Truong, Lillian, Kandhi, Sharath, Barroso, Margarida M., Takeshima, Hiroshi, Judson, Marc A., Wang, Yong-Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363799/
https://www.ncbi.nlm.nih.gov/pubmed/32669538
http://dx.doi.org/10.1038/s41467-020-17314-1

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