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Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly
In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying mechanism remains unclear. Here, we used single-mo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363831/ https://www.ncbi.nlm.nih.gov/pubmed/32669573 http://dx.doi.org/10.1038/s41598-020-68476-3 |