Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

The pathogenesis of declining bone mineral density, a universal feature of ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in human tissues and mounting evidence suggests that they may be integral to the ageing process. To explore the potential effect...

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Detalles Bibliográficos
Autores principales: Dobson, Philip F., Dennis, Ella P., Hipps, Daniel, Reeve, Amy, Laude, Alex, Bradshaw, Carla, Stamp, Craig, Smith, Anna, Deehan, David J., Turnbull, Doug M., Greaves, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363892/
https://www.ncbi.nlm.nih.gov/pubmed/32669663
http://dx.doi.org/10.1038/s41598-020-68566-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363892/
https://www.ncbi.nlm.nih.gov/pubmed/32669663
http://dx.doi.org/10.1038/s41598-020-68566-2

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