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Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss
The pathogenesis of declining bone mineral density, a universal feature of ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in human tissues and mounting evidence suggests that they may be integral to the ageing process. To explore the potential effect...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363892/ https://www.ncbi.nlm.nih.gov/pubmed/32669663 http://dx.doi.org/10.1038/s41598-020-68566-2 |