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Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
The aim of this study is to investigate whether GGT variability is able to predict the risk of end-stage renal disease (ESRD). The study subjects were Koreans who conducted health exams supported by the Korean National Health Insurance Corporation during 2009–2012 (baseline). After excluding individ...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363906/ https://www.ncbi.nlm.nih.gov/pubmed/32669624 http://dx.doi.org/10.1038/s41598-020-68603-0 |
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author | Lee, Da Young Han, Kyungdo Yu, Ji Hee Park, Sanghyun Heo, Jee-In Seo, Ji A. Kim, Nam Hoon Yoo, Hye Jin Kim, Sin Gon Kim, Seon Mee Choi, Kyung Mook Baik, Sei Hyun Park, Yong Gyu Kim, Nan Hee |
author_facet | Lee, Da Young Han, Kyungdo Yu, Ji Hee Park, Sanghyun Heo, Jee-In Seo, Ji A. Kim, Nam Hoon Yoo, Hye Jin Kim, Sin Gon Kim, Seon Mee Choi, Kyung Mook Baik, Sei Hyun Park, Yong Gyu Kim, Nan Hee |
author_sort | Lee, Da Young |
collection | PubMed |
description | The aim of this study is to investigate whether GGT variability is able to predict the risk of end-stage renal disease (ESRD). The study subjects were Koreans who conducted health exams supported by the Korean National Health Insurance Corporation during 2009–2012 (baseline). After excluding individuals aged < 40 years, heavy alcoholics, or those with histories of chronic liver disease or ESRD, we followed 6,058,995 individuals. We calculated the average successive variability (ASV) of GGT values during the 5 years before the baseline as a parameter of variability. Using Cox proportional analyses, we evaluated the risk of ESRD according to GGT ASV quartiles, defined as the initiation of renal replacement therapy or kidney transplantation, or December 31, 2016. During 38,663,279.3 person-years of follow-up, 12,057 cases of ESRD were identified. Compared with GGT ASV quartile 1, the risk of ESRD was higher in ASV quartiles 3–4 and increased serially, even after adjustment for several metabolic parameters, baseline renal function, presence of comorbidities, low income, and baseline GGT and hemoglobin level. The fully adjusted hazard ratios (95% confidence intervals) of GGT ASV quartiles 3 and 4 were 1.06 (1.01–1.12) and 1.12 (1.06–1.18), respectively. In conclusion, GGT variability is a putative risk factor for ESRD in Koreans. |
format | Online Article Text |
id | pubmed-7363906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73639062020-07-17 Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study Lee, Da Young Han, Kyungdo Yu, Ji Hee Park, Sanghyun Heo, Jee-In Seo, Ji A. Kim, Nam Hoon Yoo, Hye Jin Kim, Sin Gon Kim, Seon Mee Choi, Kyung Mook Baik, Sei Hyun Park, Yong Gyu Kim, Nan Hee Sci Rep Article The aim of this study is to investigate whether GGT variability is able to predict the risk of end-stage renal disease (ESRD). The study subjects were Koreans who conducted health exams supported by the Korean National Health Insurance Corporation during 2009–2012 (baseline). After excluding individuals aged < 40 years, heavy alcoholics, or those with histories of chronic liver disease or ESRD, we followed 6,058,995 individuals. We calculated the average successive variability (ASV) of GGT values during the 5 years before the baseline as a parameter of variability. Using Cox proportional analyses, we evaluated the risk of ESRD according to GGT ASV quartiles, defined as the initiation of renal replacement therapy or kidney transplantation, or December 31, 2016. During 38,663,279.3 person-years of follow-up, 12,057 cases of ESRD were identified. Compared with GGT ASV quartile 1, the risk of ESRD was higher in ASV quartiles 3–4 and increased serially, even after adjustment for several metabolic parameters, baseline renal function, presence of comorbidities, low income, and baseline GGT and hemoglobin level. The fully adjusted hazard ratios (95% confidence intervals) of GGT ASV quartiles 3 and 4 were 1.06 (1.01–1.12) and 1.12 (1.06–1.18), respectively. In conclusion, GGT variability is a putative risk factor for ESRD in Koreans. Nature Publishing Group UK 2020-07-15 /pmc/articles/PMC7363906/ /pubmed/32669624 http://dx.doi.org/10.1038/s41598-020-68603-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lee, Da Young Han, Kyungdo Yu, Ji Hee Park, Sanghyun Heo, Jee-In Seo, Ji A. Kim, Nam Hoon Yoo, Hye Jin Kim, Sin Gon Kim, Seon Mee Choi, Kyung Mook Baik, Sei Hyun Park, Yong Gyu Kim, Nan Hee Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
title | Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
title_full | Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
title_fullStr | Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
title_full_unstemmed | Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
title_short | Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
title_sort | gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363906/ https://www.ncbi.nlm.nih.gov/pubmed/32669624 http://dx.doi.org/10.1038/s41598-020-68603-0 |
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