Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neutrophil mobilization in acute inflammation is not c...

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Detalles Bibliográficos
Autores principales: Khatib-Massalha, Eman, Bhattacharya, Suditi, Massalha, Hassan, Biram, Adi, Golan, Karin, Kollet, Orit, Kumari, Anju, Avemaria, Francesca, Petrovich-Kopitman, Ekaterina, Gur-Cohen, Shiri, Itkin, Tomer, Brandenburger, Isabell, Spiegel, Asaf, Shulman, Ziv, Gerhart-Hines, Zachary, Itzkovitz, Shalev, Gunzer, Matthias, Offermanns, Stefan, Alon, Ronen, Ariel, Amiram, Lapidot, Tsvee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363928/
https://www.ncbi.nlm.nih.gov/pubmed/32669546
http://dx.doi.org/10.1038/s41467-020-17402-2

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